Burrai I, Henderson B, Knight S C, Staines N A
Clin Exp Immunol. 1985 Aug;61(2):368-72.
Rats were immunized with type II collagen to induce polyarthritis. Spleen and lymph node cells were taken at various times and transferred to normal syngeneic animals. Disease was not observed in recipients of cells taken from donors either during the pre-clinical phase or the acute clinical phase of the disease. However, arthritis could not be induced in the recipient animals that had received cells taken from donors during the preclinical phase. Animals receiving cells from donors with clinical disease appeared to have a normal susceptibility to disease induced subsequently. In contrast with the differences in their susceptibility to induced disease, all recipient animals made unmodified antibody responses to a challenging injection of type II collagen. The results showed that before the appearance of clinical disease in CII immunized rats, there were cells in the spleen and lymph nodes that inhibit the development of disease but not antibody responses.
用II型胶原免疫大鼠以诱导多关节炎。在不同时间采集脾脏和淋巴结细胞，并将其转移至同基因正常动物体内。在疾病的临床前期或急性临床期，接受来自供体的细胞的受体动物均未观察到疾病。然而，在临床前期接受来自供体的细胞的受体动物中无法诱导出关节炎。接受来自患有临床疾病的供体的细胞的动物对随后诱导的疾病似乎具有正常的易感性。与它们对诱导疾病的易感性差异相反，所有受体动物对II型胶原的激发注射均产生未改变的抗体反应。结果表明，在CII免疫大鼠出现临床疾病之前，脾脏和淋巴结中存在抑制疾病发展但不抑制抗体反应的细胞。
