放射治疗对通用粘合剂牙本质粘结强度的影响。

Effect of radiation therapy on the dentin bond strength of a universal adhesive.

作者信息

Saikaew Pipop, Hannongbua P, Jianratanajit P, Wongkertprayot I, Chaiklahan P, Srimaneekarn N, Prayongrat A, Eamsa-Ard P, Chowdhury Afma, Katekovit K, Hidehiko S

机构信息

Department of Operative Dentistry and Endodontics, Faculty of Dentistry, Mahidol University, 6 Yothi Road, Ratchathewi, Bangkok, 10400, Thailand.

Faculty of Dentistry, Mahidol University, 6 Yothi Road, Ratchathewi, Bangkok, 10400, Thailand.

出版信息

BMC Oral Health. 2025 May 27;25(1):812. doi: 10.1186/s12903-025-06226-5.

DOI:10.1186/s12903-025-06226-5

PMID:40426161

Abstract

BACKGROUND

Successful restorative procedures, particularly for patients undergoing head and neck radiotherapy, rely on a robust adhesive interface. Since radiotherapy may alter dental tissues and compromise bonding, this study evaluated how the timing of radiation exposure affects the microtensile bond strength (µTBS) of a universal adhesive to dentin with different application modes.

METHODS

Forty-two human third molars were used in this study. Mid-coronal dentin was prepared using a low-speed saw and polished with silicon carbide paper. The samples were randomly divided into 3 groups (n = 6) according to the timing of radiation exposure (no radiation, control; radiation after restoration, F-RT; and radiation before restoration, RT-F). A single radiation dose of 70 Gy was administered to the samples after restoration (F-RT) and before restoration (RT-F). The samples were further divided into 2 subgroups according to the application mode of a universal adhesive (Single Bond Universal adhesive, 3 M Oral Care, St. Paul, MN, USA): etch-and-rinse (ER) or self-etch (SE) mode. After adhesive application, the resin composite was constructed and stored in distilled water at 37 °C for 24 h. Six resin-bonded teeth per group were processed for the µTBS test. The data were analyzed by two-way ANOVA followed by Duncan's test (p < 0.05). Fractured surfaces were observed under a scanning electron microscope (SEM). Additional teeth were prepared for resin‒dentin interface observation (n = 1) and observed using an SEM.

RESULTS

The application mode of the universal adhesive had no influence on the µTBS of dentin, regardless of irradiation (p = 0.670). The µTBS values of the control groups were not significantly different from those of the F-RT group but were significantly higher than those of the RT-F group for both application modes. The resin‒dentin interfaces of the samples were similar among the control, F-RT and RT-F groups. More abundant and longer resin tags were observed when the universal adhesive was bonded in ER mode.

CONCLUSION

Compared with radiation after restoration, radiation before restoration resulted in an inferior bond strength. The application mode of a universal adhesive had no effect on the bond strength.

CLINICAL SIGNIFICANCE

Restoration prior to the radiation procedure is an advisable strategy.

摘要

背景

成功的修复程序，特别是对于接受头颈部放疗的患者，依赖于稳固的粘结界面。由于放疗可能会改变牙体组织并损害粘结效果，本研究评估了放疗暴露时间对一种通用粘结剂在不同应用模式下与牙本质的微拉伸粘结强度（µTBS）的影响。

方法

本研究使用了42颗人类第三磨牙。使用低速锯制备牙冠中部牙本质，并用碳化硅纸进行抛光。根据放疗暴露时间将样本随机分为3组（n = 6）：无放疗组（对照组）；修复后放疗组（F-RT）；修复前放疗组（RT-F）。对修复后（F-RT）和修复前（RT-F）的样本给予单次70 Gy的辐射剂量。根据通用粘结剂（美国明尼苏达州圣保罗市3M口腔护理公司的Single Bond Universal粘结剂）的应用模式，将样本进一步分为2个亚组：酸蚀冲洗（ER）模式或自酸蚀（SE）模式。粘结剂应用后，构建树脂复合体并在37°C蒸馏水中储存24小时。每组处理6颗粘结牙进行µTBS测试。数据采用双向方差分析，随后进行邓肯检验（p < 0.05）。在扫描电子显微镜（SEM）下观察断裂面。制备额外的牙齿用于树脂-牙本质界面观察（n = 1），并使用SEM进行观察。