Di Carlo Paola, Serra Nicola, Collotta Ornella, Colomba Claudia, Firenze Alberto, Aprea Luigi, Distefano Salvatore Antonino, Cortegiani Andrea, Giammanco Giovanni, Fasciana Teresa Maria Assunta, Virruso Roberta, Capuano Angela, Sergi Consolato M, Cascio Antonio
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy.
Department of Neuroscience, Reproductive Sciences and Dentistry Department, Audiology Section "Federico II" University of Naples Federico II, 80131 Naples, Italy.
Antibiotics (Basel). 2025 Apr 29;14(5):452. doi: 10.3390/antibiotics14050452.
: Various factors associated with seasonality, including temperature, humidity, geographical composition, and seasonal fluctuations, can influence the trends of microbes responsible for hospital infections, such as spp. This study evaluates the seasonal variability of Candida spp. bloodstream infections and antifungal resistance in hospitalized patients in Sicily. : We retrospectively analyzed the demographic and epidemiological characteristics of 175 patients with blood cultures positive for spp. Who were hospitalized at University Hospital Paolo Giaccone (A.U.O.P.), University of Palermo, Italy, from 1 January 2022 to 31 December 2024. Data on species and antifungal resistance were also collected from the hospital's database system to prevent and control hospital infections in A.U.O.P. : A total of 175 patients, 57.7% males, with a mean age of 68.3 years, were included in this study. , , and were more frequent in ICU (54.5%, = 0.0001), medical (72.5%, = 0.0003), and surgical settings (24%, = 0.0161), respectively. more frequent in dead patients (53.2%, = 0.005). Among the seasons, we observed a significantly higher presence of in Autumn (20%, = 0.0436). From the analysis of the seasons, . and . albicans were more frequent for each season, except in Spring, where the most frequent isolates were . (5.1%, = 0.0237) and C. (9.7%, < 0.0001). The antifungal with the most resistance to spp. was fluconazole in all seasons. : Our study highlights the seasonal trends in spp. and antifungal resistance, emphasizing climate change's challenges on fungal diseases. These findings may contribute to improving prevention and treatment strategies for candidemia.
与季节性相关的各种因素，包括温度、湿度、地理构成和季节性波动，都可能影响导致医院感染的微生物趋势，如 属。本研究评估了西西里岛住院患者中念珠菌属血流感染的季节性变化及抗真菌耐药性。：我们回顾性分析了2022年1月1日至2024年12月31日期间在意大利巴勒莫大学保罗·贾科内大学医院（A.U.O.P.）住院的175例血培养 属阳性患者的人口统计学和流行病学特征。还从医院数据库系统收集了有关 菌种和抗真菌耐药性的数据，以预防和控制A.U.O.P.的医院感染。：本研究共纳入175例患者，其中男性占57.7%，平均年龄为68.3岁。 、 和 在重症监护病房（54.5%， = 0.0001）、内科（72.5%， = 0.0003）和外科环境（24%， = 0.0161）中分别更为常见。 在死亡患者中更为常见（53.2%， = 0.005）。在各个季节中，我们观察到秋季 的存在显著更高（20%， = 0.0436）。从季节分析来看，。 和白色念珠菌在每个季节中更为常见，但春季除外，春季最常见的分离株是 （5.1%， = 0.0237）和光滑念珠菌（9.7%， < 0.0001）。在所有季节中，对 属耐药性最强的抗真菌药物是氟康唑。：我们的研究突出了 属的季节性趋势和抗真菌耐药性，强调了气候变化对真菌疾病的挑战。这些发现可能有助于改进念珠菌血症的预防和治疗策略。
