Woźniacka Anna, Tokarska Kamila, Żmuda Bartlomiej
Department of Dermatology and Venereology, Medical University of Lodz, 90-419 Łódź, Poland.
J Clin Med. 2025 May 15;14(10):3469. doi: 10.3390/jcm14103469.
Alopecia areata is regarded as a T cell-mediated autoimmune disorder, but the exact etiopathogenesis of the disease has not been completely elucidated. The aim of the study was to assess vascular circulation using Flow-Mediated Skin Fluorescence (FMSF) in alopecia patients compared to healthy volunteers, which could explain disease pathogenesis. FMSF is a new non-invasive method for assessing vascular circulation. The study recruited thirty women and four men. In our group, the most common clinical pattern of hair loss was alopecia with circular patches (AA), recognizable in 26 patients: twenty-two women and four men. Alopecia universalis (AU) was diagnosed in eight patients: all women. The most pronounced differences between experimental group participants and controls are seen in the flowmotion (FM), neurogenic oscillation (NEURO), and normoxia oscillatory index (NOI) parameters characterizing microcirculation oscillations. In alopecia, microcirculation oscillations characterized by the FM and NEURO parameters are significantly decreased. This observation may suggest that neuroinflammation is an important factor responsible for alopecia pathogenesis. The women with alopecia areata have dysfunctional microcirculatory function. FMSF could serve as a useful tool for monitoring patients with alopecia.
斑秃被认为是一种由T细胞介导的自身免疫性疾病，但该疾病的确切发病机制尚未完全阐明。本研究的目的是通过血流介导的皮肤荧光（FMSF）评估斑秃患者与健康志愿者的血管循环情况，这可能有助于解释疾病的发病机制。FMSF是一种评估血管循环的新型非侵入性方法。该研究招募了30名女性和4名男性。在我们的研究组中，最常见的脱发临床模式是圆形斑片状脱发（AA），26名患者可识别出这种症状：22名女性和4名男性。8名患者被诊断为全秃（AU）：均为女性。实验组参与者与对照组之间最显著的差异体现在表征微循环振荡的血流运动（FM）、神经源性振荡（NEURO）和常氧振荡指数（NOI）参数上。在斑秃中，以FM和NEURO参数表征的微循环振荡显著降低。这一观察结果可能表明神经炎症是斑秃发病机制中的一个重要因素。斑秃女性患者存在微循环功能障碍。FMSF可作为监测斑秃患者的有用工具。
