Yamori Y, Mori C, Nishio T, Ooshima A, Horie R, Ohtaka M, Soeda T, Saito M, Abe K, Nara Y, Nakao Y, Kihara M
Am J Cardiol. 1979 Oct 22;44(5):964-9. doi: 10.1016/0002-9149(79)90230-3.
Studies of cardiac hypertrophy in spontaneously hypertensive rats have indicated that left ventricular hypertrophy occurred even in the prehypertensive stage. These findings suggested that other factors besides blood pressure levels, and including possibly a genetic predisposition to myocardial hypertrophy, could play a role in structural cardiovascular alterations in spontaneously hypertensive rats. More recent studies have confirmed these anatomic results; left ventricular hypertrophy was vectorcardiographically detected even in the prehypertensive stage in voth young stroke-prone rats and stroke-resistant spontaneously hypertensive rats. Further, a close relation was found between degree of left ventricular hypertrophy and vascular hypertrophy or hyperplasia; this suggests that early detection of left ventricular hypertrophy may be a useful indicator of the incipient stage of structural vascular changes in genetic hypertension.
对自发性高血压大鼠心脏肥大的研究表明，即使在高血压前期阶段左心室就已出现肥大。这些发现提示，除血压水平外的其他因素，可能包括心肌肥大的遗传易感性，在自发性高血压大鼠的心血管结构改变中发挥作用。最近的研究证实了这些解剖学结果；在易发生中风的年轻大鼠和抗中风自发性高血压大鼠的高血压前期阶段，通过向量心电图均检测到了左心室肥大。此外，还发现左心室肥大程度与血管肥大或增生之间存在密切关系；这表明，早期检测左心室肥大可能是遗传性高血压中血管结构改变初期阶段的一个有用指标。
