Omidian Hossein, Wilson Renae L
Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Pharmaceuticals (Basel). 2025 Apr 27;18(5):631. doi: 10.3390/ph18050631.
Poly(lactide--glycolide) (PLGA) implants have become a cornerstone in drug delivery and regenerative medicine due to their biocompatibility, tunable degradation, and capacity for sustained, localized therapeutic release. Recent innovations in polymer design, fabrication methods, and functional modifications have expanded their utility across diverse clinical domains, including oncology, neurology, orthopedics, and ophthalmology. This review provides a comprehensive analysis of PLGA implant properties, fabrication strategies, and biomedical applications, while addressing key challenges such as burst release, incomplete drug release, manufacturing complexity, and inflammatory responses. Emerging solutions-such as 3D printing, in situ forming systems, predictive modeling, and patient-specific customization-are improving implant performance and clinical translation. Emphasis is placed on scalable production, long-term biocompatibility, and personalized design to support the next generation of precision therapeutics.
聚（丙交酯-乙交酯）（PLGA）植入物因其生物相容性、可调节降解性以及持续局部治疗释放的能力，已成为药物递送和再生医学的基石。聚合物设计、制造方法和功能修饰方面的最新创新扩大了它们在包括肿瘤学、神经病学、骨科和眼科在内的各种临床领域的应用。本综述对PLGA植入物的特性、制造策略和生物医学应用进行了全面分析，同时解决了诸如突释、药物释放不完全、制造复杂性和炎症反应等关键挑战。新兴解决方案，如3D打印、原位成型系统、预测建模和个性化定制，正在改善植入物性能和临床转化。重点在于可扩展生产、长期生物相容性和个性化设计，以支持下一代精准治疗。
