中国的妊娠高血压与动脉粥样硬化性心血管疾病风险评分

Pregnancy-Induced Hypertension and Atherosclerotic Cardiovascular Disease Risk Score in China.

作者信息

He Honghong, Sun Junyan, Huo Hongqiu, Wang Yanxiu, Wu Yuntao, Chen Suhua, Wang Yangyang, Zheng Xiaoming, Zhao Haiyan

机构信息

Department of Cardiology, Kailuan General Hospital, Tangshan, China.

Department of Traditional Chinese Medicine, Kailuan General Hospital, Tangshan, China.

出版信息

CJC Open. 2025 Jan 11;7(4):435-440. doi: 10.1016/j.cjco.2025.01.006. eCollection 2025 Apr.

DOI:10.1016/j.cjco.2025.01.006

PMID:40433141

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12105747/

Abstract

BACKGROUND

Pregnancy-induced hypertension (PIH) poses a significant threat to maternal health. This study aims to explore the association between PIH and the risk of atherosclerotic cardiovascular disease (ASCVD).

METHODS

The cohort comprised 1947 pregnant women delivering a single child between 2004 and 2020 in the Kailuan study. Participants, categorized into PIH and non-PIH (NPIH) groups based on PIH history, completed questionnaires and underwent physical examinations and laboratory assessments within 2 years after delivery. Predicted ASCVD risks used the Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) model, distinguishing lifetime ASCVD risk as "low" (<32.8%) and "high" (≥32.8%). χ tests and logistic regression were used to investigate the association between PIH and high lifetime risk China-PAR categories.

RESULTS

Overall, 6.17% of the PIH group had high lifetime risk, compared with 0.96% in the NPIH group (χ 29.59, < 0.001). After adjusting for confounders, PIH was independently associated with high-risk China-PAR categories, with the PIH group having a 5.03 times higher probability than the NPIH group (95% CI 2.20-11.51, < 0.01).

CONCLUSION

Pregnancy-induced hypertension was associated with increased lifetime risk of ASCVD.

摘要

背景

妊娠期高血压（PIH）对孕产妇健康构成重大威胁。本研究旨在探讨PIH与动脉粥样硬化性心血管疾病（ASCVD）风险之间的关联。

方法

该队列包括1947名在开滦研究中于2004年至2020年间分娩单胎的孕妇。参与者根据PIH病史分为PIH组和非PIH（NPIH）组，在分娩后2年内完成问卷调查，并接受体格检查和实验室评估。预测的ASCVD风险使用中国动脉粥样硬化性心血管疾病风险（China-PAR）模型，将终生ASCVD风险分为“低”（<32.8%）和“高”（≥32.8%）。采用χ检验和逻辑回归分析来研究PIH与高终生风险China-PAR类别之间的关联。