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长效驱虫蚊帐在老挝消除疟疾中的有效性(2016 - 2023年)

Effectiveness of long-lasting insecticidal nets for malaria elimination in Laos (2016-2023).

作者信息

Navalith Nouanthong, Jeong Heon Jae, Yang Yeun Soo, Phonethipsavanh Nouanthong, Kim Sangyune, Kang Sunjoo

机构信息

Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea.

The Care Quality Institute, Seoul, Republic of Korea.

出版信息

Malariaworld J. 2025 May 21;16:11. doi: 10.5281/zenodo.15479515. eCollection 2025.

Abstract

INTRODUCTION

Malaria remains a significant health challenge in Laos, particularly in the southern provinces with dense forests and mobile populations. Despite progress in reducing cases, socio-environmental factors drive its persistence.

MATERIALS AND METHODS

Using data from 2016 to 2023, trends were analysed with P-trend analysis, and effects of long-lasting insecticidal nets (LLIN) and climate on malaria incidence were assessed via Poisson regression.

RESULTS

During this period, malaria incidence decreased by 95.5%, underscoring the success of elimination strategies. LLIN distribution led to a 54.1% reduction in incidence (IRR=0.459; p 0.002). Climate factors did not significantly influence transmission rates (IRR=0.67; p 0.717).

CONCLUSIONS

The critical role of LLINs in reducing malaria incidence is evident. To support the national elimination goal for 2030, interventions must maintain consistent coverage and community engagement. Future research should focus on localised climatic data and address specific challenges in regions like Khammouane Province, enhancing the effectiveness of malaria control programmes and improving intervention strategies.

摘要

引言

疟疾仍是老挝面临的一项重大健康挑战,尤其是在森林茂密且人口流动的南部省份。尽管在减少病例方面取得了进展,但社会环境因素导致疟疾持续存在。

材料与方法

利用2016年至2023年的数据,采用P趋势分析对趋势进行分析,并通过泊松回归评估长效驱虫蚊帐(LLIN)和气候对疟疾发病率的影响。

结果

在此期间,疟疾发病率下降了95.5%,突出了消除策略的成功。长效驱虫蚊帐的分发使发病率降低了54.1%(发病率比=0.459;p<0.002)。气候因素对传播率没有显著影响(发病率比=0.67;p=0.717)。

结论

长效驱虫蚊帐在降低疟疾发病率方面的关键作用显而易见。为支持2030年的国家消除目标,干预措施必须保持持续覆盖并促进社区参与。未来的研究应聚焦于本地化气候数据,并应对像甘蒙省这样的地区的特定挑战,提高疟疾控制项目的有效性并改进干预策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d641/12107291/999a0a369b33/MWJ-16-11-f1.jpg

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