来自……茎和枝的具有抗炎活性的倍半萜类化合物。 （你提供的原文似乎不完整，缺少具体植物名称等关键信息）
Sesquiterpenes with anti-inflammatory activity from the stems and branches of .
作者信息
Li Sai, Du En-Lian, Gong Qi, Chen Fei, Tan Jun-Jie, Qu Shi-Jin, Zhang Hai-Yan, Tan Chang-Heng
机构信息
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Natural Product Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
出版信息
J Asian Nat Prod Res. 2025 Jul;27(7):977-982. doi: 10.1080/10286020.2025.2508874. Epub 2025 May 28.
Five new sesquiterpenes comprising three zieranes, melicopatulones A-C (-) and two guaianes, melicopatulones D-E (-), were isolated from the stems and branches of , together with melicodenones B (), C () and D (). Their structures with absolute configurations were elucidated on the basis of analysis of MS, NMR, and TDDFT-ECD calculations. Sesquiterpenes , and exhibited significant inhibitory effect at 10 µM on lipopolysaccharide-induced NO production in BV-2 microglial cells.
从[植物名称]的茎和枝中分离出了5种新的倍半萜，包括3种蛇床烷型化合物，即九里香杷酮A-C（-），以及2种愈创木烷型化合物，即九里香杷酮D-E（-），同时还分离出了九里香酮B（）、C（）和D（）。基于质谱（MS）、核磁共振（NMR）分析以及含时密度泛函理论电子圆二色光谱（TDDFT-ECD）计算，阐明了它们的结构及其绝对构型。倍半萜化合物、和在浓度为10 µM时，对脂多糖诱导的BV-2小胶质细胞中一氧化氮（NO）的产生具有显著抑制作用。
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