Choi Mi Soo, Yeom Kyujin, Kim Myung Hwa, Park Byung Cheol
Department of Dermatology, Dankook University Hospital, 201, Manghyang-ro, Dongnam-gu, Cheonan, Chungcheongnam-do, Republic of Korea.
Dankook University - Cheonan Campus, Beckman Laser Institute Korea, Cheonan, Chungcheongnam-do, Republic of Korea.
Lasers Med Sci. 2025 May 29;40(1):249. doi: 10.1007/s10103-025-04475-y.
Monopolar radiofrequency(MRF) treatment is known to induce collagen contraction and remodeling in dermis. This study was conducted to evaluate safety of MRF in pre-clinical study first, and efficacy and safety in lifting and tightening of the face and upper neck in the clinical study. In pre-clinical setting, thermal imaging, and clinical and dermoscopic photography of after the procedure, and 7, 14, 30 days later were recorded. In clinical study, 23 subjects were enrolled and got 1 treatment. They were followed up at 4, 12, 24 weeks, and assessed using clinical photography. Changes in elasticity, pore number, wrinkle(%), and safety evaluation were also done. In the pre-clinical study, energy was safely delivered to the treatment area. In the clinical study, the clinical grades significantly decreased after 4, 12, and 24 weeks. Net and biological elasticity showed a significant increase at week 24. Pore count significantly decreased from week 12 and wrinkle started to decrease from week 4. Subjective satisfaction peaked in week 12. The average of pain score was 0.30 ± 0.63, and only mild adverse events were recorded. This study found that MRF deliver stable energy to the skin and have significant effect in skin laxity without complications.
已知单极射频（MRF）治疗可诱导真皮中的胶原蛋白收缩和重塑。本研究首先在临床前研究中评估MRF的安全性，然后在临床研究中评估其对面部和上颈部提升紧致的疗效和安全性。在临床前设置中，记录了术后及术后7天、14天、30天的热成像、临床和皮肤镜照片。在临床研究中，招募了23名受试者并进行了1次治疗。在第4周、12周、24周对他们进行随访，并使用临床照片进行评估。还进行了弹性、毛孔数量、皱纹（%）的变化以及安全性评估。在临床前研究中，能量被安全地输送到治疗区域。在临床研究中，第4周、12周和24周后临床分级显著降低。净弹性和生物弹性在第24周时显著增加。毛孔数量从第12周开始显著减少，皱纹从第4周开始减少。主观满意度在第12周达到峰值。疼痛评分平均为0.30±0.63，仅记录到轻微不良事件。本研究发现，MRF能向皮肤输送稳定能量，对皮肤松弛有显著效果且无并发症。
