Qing Guangwei, Tu Jiakuan, He Hao, Su Mengqian, Chen Yan, Wei Bo, Yang Yuanjian, Zhang Bin, Yang Guang
Department of Neurology, Kunshan Hospital of Traditional Chinese Medicine, Suzhou, Zhejiang, China.
Department of Psychiatry, Jiangxi Mental Hospital & Affiliated Mental Hospital of Nanchang University, Nanchang, 330029, Jiangxi, China.
Eat Weight Disord. 2025 May 29;30(1):45. doi: 10.1007/s40519-025-01755-y.
Suicidal ideation (SI) poses a significant public health challenge, and understanding its predictors, especially modifiable factors like visceral obesity, is essential for prevention. The purpose of this study is to investigate the association between the visceral adiposity index (VAI) and suicidal ideation (SI) among adults in the United States.
A cross-sectional study using NHANES data from 2005-2018 included adults aged 18 and above with complete SI and VAI data. Suicidal thoughts were evaluated using item 9 from the Patient Health Questionnaire-9 (PHQ-9), while VAI was calculated using gender-specific formulas based on waist circumference, body mass index (BMI), total triglycerides (TG), and high-density lipoproteins (HDL-C). Multivariate logistic regression analysis was implemented after adjusting for several factors to assess the relationship between VAI and SI. Additionally, subgroup analysis and interaction testing were employed to investigate the consistency of this relationship with other demographic parameters.
Our study included a cohort of 15,830 participants, of whom 3.59% exhibited signs of suicidal ideation. Following multivariate logistic regression analysis, we observed a significant positive association between VAI and SI (odds ratio [OR] = 1.03; 95% CI 1.01, 1.04; P = 0.0057), which remained significant after adjusting for various confounding factors. Moreover, utilizing a two-segment linear regression approach, we uncovered a nonlinear relationship between VAI and SI, demonstrating a U-shaped pattern with a critical point at 5.28.
Elevated levels of VAI were consistently associated with an increased probability of SI, and this association remained consistent across various demographic variables. Level of evidence Level V-cross-sectional observational study.
自杀意念（SI）对公共卫生构成重大挑战，了解其预测因素，尤其是像内脏肥胖这样可改变的因素，对于预防自杀至关重要。本研究的目的是调查美国成年人内脏脂肪指数（VAI）与自杀意念（SI）之间的关联。
一项横断面研究使用了2005 - 2018年美国国家健康与营养检查调查（NHANES）的数据，纳入了18岁及以上有完整自杀意念和内脏脂肪指数数据的成年人。使用患者健康问卷-9（PHQ-9）中的第9项评估自杀想法，而内脏脂肪指数则根据腰围、体重指数（BMI）、总甘油三酯（TG）和高密度脂蛋白（HDL-C），通过特定性别的公式计算得出。在对多个因素进行调整后，进行多变量逻辑回归分析，以评估内脏脂肪指数与自杀意念之间的关系。此外，采用亚组分析和交互作用检验来研究这种关系与其他人口统计学参数的一致性。
我们的研究纳入了15830名参与者，其中3.59%表现出自杀意念的迹象。经过多变量逻辑回归分析，我们观察到内脏脂肪指数与自杀意念之间存在显著的正相关（优势比[OR] = 1.03；95%置信区间1.01，1.04；P = 0.0057），在调整各种混杂因素后，这种相关性仍然显著。此外，利用两段线性回归方法，我们发现内脏脂肪指数与自杀意念之间存在非线性关系，呈现出U形模式，临界点为5.28。
内脏脂肪指数升高与自杀意念的可能性增加始终相关，并且这种关联在各种人口统计学变量中保持一致。证据级别：V级横断面观察性研究。
