Kollmeier H, Witting C, Seemann J, Wittig P, Rothe R
J Cancer Res Clin Oncol. 1985;110(2):173-6. doi: 10.1007/BF00402735.
In random autopsies chromium (n = 23) and nickel (n = 16) together with various other metals, were determined in lung tissue by means of flameless atomic absorption spectrometry. With increasing age a significant increase in concentration of both chromium and nickel was found. This is evaluated as an indicator for a corresponding exposure, which is marked by a local (workplace) and regional (environment) share of a clear increase in the total chromium/nickel load and by a life-long duration. The question arises, whether the selective concentration (long half-life) of the inhaled chromium and nickel particles/compounds in the lung are to be regarded as a stochastic lung cancer risk.
在随机尸检中，通过无火焰原子吸收光谱法测定了23例肺部组织中的铬以及16例肺部组织中的镍，同时还测定了其他各种金属。随着年龄的增长，发现铬和镍的浓度均显著增加。这被评估为相应暴露的一个指标，其特征在于局部（工作场所）和区域（环境）对总铬/镍负荷明显增加的贡献以及终生暴露时间。问题在于，吸入的铬和镍颗粒/化合物在肺部的选择性富集（半衰期长）是否应被视为一种导致肺癌的随机风险。
