von Huth Smith Lisa, Whalley Diane, Yarr Stuart, Comins Jonathan, Fehnel Sheri E
Novo Nordisk A/S, Søborg, Denmark.
Patient-Centered Outcomes Assessment, RTI Health Solutions, Towers Business Park, Manchester, UK.
Clin Obes. 2025 Aug;15(4):e70015. doi: 10.1111/cob.70015. Epub 2025 Jun 1.
The Impact of Weight on Daily Activities Questionnaire (IWDAQ) is a patient-reported outcome measure that uses a novel, adaptive design to assess the limitations in daily activities that are most important to individuals attempting to lose weight. During the first round of completing the IWDAQ, respondents are presented with 18 everyday activities that can be limited by excess weight and asked to choose the three activities they would most like to see improve with weight loss. They are then asked to rate the degree of limitation they experience with these three activities at baseline and at follow-up assessments. Using data from a weight-management clinical trial (OASIS 1, NCT05035095), we evaluated the IWDAQ's measurement properties, determined optimal scoring, and estimated thresholds of meaningful within-patient change. Our analyses demonstrated that the IWDAQ Composite Score offers a reliable and valid personalized measure of limitations in daily activities due to excess weight. The adaptive design of the IWDAQ ensures the patient-centricity of the measure, thereby complementing existing measures of functioning in the context of weight-management clinical trials. Evaluations using data from additional studies would be valuable in extending the psychometric evidence for the IWDAQ.
体重对日常活动的影响问卷（IWDAQ）是一种患者报告的结局指标，它采用新颖的自适应设计来评估对试图减肥的个体最重要的日常活动中的限制。在第一轮完成IWDAQ时，向受访者展示18项可能因超重而受限的日常活动，并要求他们选择三项最希望随着体重减轻而得到改善的活动。然后要求他们对在基线和随访评估时这三项活动所经历的受限程度进行评分。利用一项体重管理临床试验（OASIS 1，NCT05035095）的数据，我们评估了IWDAQ的测量特性，确定了最佳评分，并估计了患者内部有意义变化的阈值。我们的分析表明，IWDAQ综合评分提供了一种可靠且有效的个性化指标，用于衡量因超重导致的日常活动受限情况。IWDAQ的自适应设计确保了该指标以患者为中心，从而在体重管理临床试验背景下补充了现有的功能指标。使用来自其他研究的数据进行评估，对于扩展IWDAQ的心理测量学证据将是有价值的。
