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使用小切口植入脱钙皮质松质骨支架进行组织工程软骨修复

Tissue Engineered Cartilage Repair Using Small-Incision Implantation of Decalcified Corticocancellous Bone Scaffold.

作者信息

Liu Zhenlong, Hou Zhenchen, Pan Tong, Ye Weixin, Liu Chang, Ao Yingfang, Gong Xi

机构信息

Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing, China.

Beijing Key Laboratory of Sports Injuries, Beijing, China.

出版信息

Arthrosc Tech. 2024 Dec 10;14(4):103346. doi: 10.1016/j.eats.2024.103346. eCollection 2025 Apr.

DOI:10.1016/j.eats.2024.103346
PMID:40453027
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12126038/
Abstract

Treatment of cartilage injuries is a prominent topic internationally. Recently, tissue engineering has been used to repair cartilage injury. In China, several scaffolds have been approved for clinical trials aimed at cartilage repairing. The successful implantation of scaffold in cartilage defect areas is crucial for effective treatment. The procedure is crucial in ensuring that the scaffold is implanted successfully, which is fundamental for a good prognosis. International reports on tissue-engineered scaffold implantation technologies highlight both advantages and disadvantages. Because of limitations in the required equipment and materials, some of the surgical techniques used internationally are not applicable in China. To optimize the technology of tissue-engineered scaffolds for cartilage repair in China, this Technical Note discusses the implantation techniques and skills involved, focusing on small-incision implantation of decalcified cortex-cancellous bone scaffolds. This work contributes to standardizing the surgical procedures for tissue engineering scaffold technology in repairing cartilage injuries.

摘要

软骨损伤的治疗是国际上一个备受关注的话题。近年来,组织工程已被用于修复软骨损伤。在中国,已有几种支架被批准用于针对软骨修复的临床试验。支架在软骨缺损区域的成功植入对于有效治疗至关重要。该手术对于确保支架成功植入至关重要,而这对于良好的预后至关重要。关于组织工程支架植入技术的国际报告既强调了优点也指出了缺点。由于所需设备和材料的限制,国际上使用的一些手术技术在中国并不适用。为了优化中国用于软骨修复的组织工程支架技术,本技术说明讨论了所涉及的植入技术和技巧,重点是脱钙皮质 - 松质骨支架的小切口植入。这项工作有助于规范组织工程支架技术修复软骨损伤的手术程序。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd4/12126038/1c9e1b21c6ef/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd4/12126038/1c9e1b21c6ef/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7cd4/12126038/1c9e1b21c6ef/gr1.jpg

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本文引用的文献

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Absorbable Nail Fixation of Biologic Membrane for Treatment of Cartilage Defects by Matrix-Induced Autologous Chondrocyte Implantation.生物膜可吸收钉固定术联合基质诱导自体软骨细胞移植治疗软骨缺损
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Arthroscopic and open approaches for autologous matrix-induced chondrogenesis repair of the knee have similar results: a meta-analysis.关节镜和开放入路自体基质诱导软骨再生修复膝关节的疗效相似:一项荟萃分析。
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Matrix-Induced Autologous Chondrocyte Implantation (MACI) is Largely Effective and Provides Significant Improvement in Patients With Symptomatic, Large Chondral Defects: A Systematic Review and Meta-Analysis.基质诱导自体软骨细胞植入术(MACI)在很大程度上是有效的,并且能使有症状的大软骨缺损患者有显著改善:一项系统评价和荟萃分析。
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MR Imaging of Knee Cartilage Injury and Repair Surgeries.磁共振成像在膝关节软骨损伤及修复手术中的应用
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Matrix-induced autologous chondrocyte implantation (mACI) versus autologous matrix-induced chondrogenesis (AMIC) for chondral defects of the knee: a systematic review.基质诱导自体软骨细胞移植(mACI)与自体基质诱导软骨形成术(AMIC)治疗膝关节软骨缺损的比较:系统评价。
Br Med Bull. 2022 Mar 21;141(1):47-59. doi: 10.1093/bmb/ldac004.
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The immune microenvironment in cartilage injury and repair.软骨损伤与修复中的免疫微环境。
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Clinical and Radiological Outcomes After Autologous Matrix-Induced Chondrogenesis Versus Microfracture of the Knee: A Systematic Review and Meta-analysis With a Minimum 2-Year Follow-up.自体基质诱导软骨形成与膝关节微骨折术后的临床及影像学结果:一项至少随访2年的系统评价和荟萃分析
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All-Arthroscopic Nanofractured Autologous Matrix-Induced Chondrogenesis (A-NAMIC) Technique for the Treatment of Focal Chondral Lesions of the Knee.全关节镜下纳米骨折自体基质诱导软骨形成(A-NAMIC)技术治疗膝关节局灶性软骨损伤
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