[正常脑脊液中的免疫球蛋白。II. 关系与指标]

[Immunoglobulins of the normal cerebrospinal fluid. II. Relations and indices].

作者信息

Livramento J A

出版信息

Arq Neuropsiquiatr. 1979 Dec;37(4):397-404. doi: 10.1590/s0004-282x1979000400005.

DOI:10.1590/s0004-282x1979000400005

Abstract

Relations and quocientes of cerebrospinal fluid (CSF) immunoglobulins G (IGG) and serum (S) IGG were studied in 50 patients with chronic headache, normal neurological examination and normal electroencephalogram. CSF was normal as to: pressure, cytology, total proteins, protein fractions and immunoglobulins (IGG, IGA and IGM) contents. In all cases the CSF sample studied was collected from cisterna magna. The relations and quocients studied were: CSF IGG/CSF TOTAL PROTEIN, CSF IGG/CSF ALBUMIN, CSF IGG/CSF PRE ALBUMIN+ALBUMIN, (CSF IGG/S IGG) / (CSF ALBUMIN/S ALBUMIN) and (CSF IGG/S IGG) / (CSF PRE ALBUMIN+ALBUMIN) / (S ALBUMIN). It was found that the best index to appraise the behavior of IGG is: (CSF IGG/S IGG) /(CSF PRE ALBUMIN+ALBUMIN/S ALBUMIN) that shows an average of 0.56 and a standard deviation of 0.32 in the material studied.

摘要

对50例慢性头痛患者进行了研究，这些患者神经系统检查和脑电图均正常。研究了脑脊液（CSF）免疫球蛋白G（IgG）与血清（S）IgG的关系和商值。脑脊液在压力、细胞学、总蛋白、蛋白组分和免疫球蛋白（IgG、IgA和IgM）含量方面均正常。所有病例中，所研究的脑脊液样本均从枕大池采集。所研究的关系和商值为：脑脊液IgG/脑脊液总蛋白、脑脊液IgG/脑脊液白蛋白、脑脊液IgG/脑脊液前白蛋白+白蛋白、（脑脊液IgG/S IgG）/（脑脊液白蛋白/S白蛋白）以及（脑脊液IgG/S IgG）/（脑脊液前白蛋白+白蛋白/S白蛋白）。结果发现，评估IgG行为的最佳指标是：（脑脊液IgG/S IgG）/（脑脊液前白蛋白+白蛋白/S白蛋白），在所研究的材料中，该指标的平均值为0.56，标准差为0.32。