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患有肌肉骨骼疼痛的儿童和青少年在全科医疗就诊时的预后及生物心理社会预后因素

Prognosis and bio-psycho-social prognostic factors in children and adolescents with musculoskeletal pain consulting general practice.

作者信息

Pourbordbari Negar, Jensen Martin Bach, Olesen Jens Lykkegaard, Holden Sinead, Rathleff Michael Skovdal

机构信息

Center for General Practice at, Aalborg University, Selma Lagerløfs Vej 249, 9260, Gistrup, Denmark.

Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Frederik Bajers Vej 7D, 9200, Aalborg, Denmark.

出版信息

Eur J Pediatr. 2025 Jun 2;184(6):384. doi: 10.1007/s00431-025-06217-2.

Abstract

UNLABELLED

To investigate the 12-months prognosis and prognostic factors of 8-19-year-olds with musculoskeletal pain in general practice. A prospective cohort was conducted in a setting of Danish general practice clinics. Participants were children and adolescents aged 8-19 years old consulting the general practitioner with self-reported musculoskeletal pain completed a questionnaire at baseline, 3-, 6-, and 12-month follow-up. No interventions were applied. The primary outcome was activity-limiting pain at 6 months, regardless of pain location. We included one hundred children and adolescents (median age 13 years interquartile range 12-16.5, 55% female) with a follow-up rate of 70% at 6 months and 67% at 12 months. The most common pain site was the knee. After 6 months, 36% reported activity-limiting pain and 42% reported multi-site pain. After 12 months, 26% reported activity-limiting pain. Children and adolescents who felt nervous (odds ratio (OR) 4.2 95% confidence interval (CI) 1.4-12.5) or tired during the day (OR 2.9 95% CI 1.1-7.7), with 1-7 days of pain episodes (OR 7.1 95% CI 1.8-28.9), who used pain medication (OR 5.4 95% CI 1.6-18.4), had difficulties falling asleep (OR 4.8 95% CI 1.7-13.9), carrying a schoolbag (OR 3.8 95% CI 1.1-13.1), or bending down to put on socks due to pain (OR 4.1 95% CI 1.3-13.2) had a higher risk of pain after 6 months.  Conclusion: One-third of adolescents consulting their GP for MSK pain continue to experience activity-limiting pain at 6 months. This highlights the need for early identification of risk factors and a biopsychosocial approach to pain management in general practice. This study was performed at the Center for General Practice at Aalborg University, Fyrkildevej 7 1st floor, 9220 Aalborg Ø, Denmark. This work was supported by the Multidisciplinary Committee (MPU) providing a grant used for compensation for the general practice clinic's time spent on recruitment [grant number ID: MPU 20-2017/date 100117].

CLINICALTRIALS

gov (Identifier NCT03678922) and link: https://clinicaltrials.gov/study/NCT03678922?term=NCT03678922&rank=1.

WHAT IS KNOWN

• Musculoskeletal pain, among other pain sites; headache and abdominal pain account for most of the recurrent painful states among children and adolescents; they may have a poorer prognosis and the MSK pain a larger impact than realized. • Many adolescents consult their GP with MSK pain, but there is a lack of data in this setting of early stage management resulting in a limitation in the current body of evidence on the prognosis of adolescent MSK pain complaints is studies based on secondary care population or school-based population.

WHAT IS NEW

• A substantial proportion of children and adolescents (36%) continue to experience activity-limiting MSK pain six months after consulting their GP, with 26% still affected after 12 months. • Children and adolescents with persistent MSK pain at six months was characterized by functional difficulties in daily activities, all linked to their pain, - one of the most notable challenges was carrying a schoolbag.

摘要

未标注

为研究8至19岁肌肉骨骼疼痛患者在全科医疗中的12个月预后及预后因素。在丹麦全科医疗诊所开展了一项前瞻性队列研究。参与者为8至19岁因自我报告的肌肉骨骼疼痛而咨询全科医生的儿童和青少年,他们在基线、3个月、6个月和12个月随访时完成了一份问卷。未实施任何干预措施。主要结局是6个月时限制活动的疼痛,无论疼痛部位如何。我们纳入了100名儿童和青少年(中位年龄13岁,四分位间距12 - 16.5岁,55%为女性),6个月时随访率为70%,12个月时为67%。最常见的疼痛部位是膝盖。6个月后,36%的人报告有活动受限疼痛,42%的人报告有多部位疼痛。12个月后,26%的人报告有活动受限疼痛。在白天感到紧张(比值比(OR)4.2,95%置信区间(CI)1.4 - 12.5)或疲倦(OR 2.9,95% CI 1.1 - 7.7)、有1 - 7天疼痛发作(OR 7.1,95% CI 1.8 - 28.9)、使用止痛药物(OR 5.4,95% CI 1.6 - 18.4)、入睡困难(OR 4.8,95% CI 1.7 - 13.9)、因疼痛背书包困难(OR 3.8,95% CI 1.1 - 13.1)或弯腰穿袜子困难(OR 4.1,95% CI 1.3 - 13.2)的儿童和青少年,6个月后疼痛风险更高。结论:因肌肉骨骼疼痛咨询全科医生的青少年中,三分之一在6个月时仍有活动受限疼痛。这凸显了在全科医疗中早期识别风险因素及采用生物心理社会方法进行疼痛管理的必要性。本研究在奥尔堡大学全科医疗中心进行,地址为丹麦奥尔堡Ø市菲基尔德韦街7号1楼,邮编9220。本研究得到多学科委员会(MPU)的支持,该委员会提供了一笔赠款,用于补偿全科医疗诊所在招募工作上花费的时间[赠款编号:MPU 20 - 2017/日期100117]。

临床试验

美国国立医学图书馆临床试验注册库(标识符NCT03678922)及链接:https://clinicaltrials.gov/study/NCT03678922?term=NCT03678922&rank=1。

已知信息

• 肌肉骨骼疼痛,在其他疼痛部位中,头痛和腹痛占儿童和青少年复发性疼痛状态的大部分;它们可能预后较差,且肌肉骨骼疼痛的影响比意识到的更大。• 许多青少年因肌肉骨骼疼痛咨询全科医生,但在这种早期管理背景下缺乏数据,导致目前关于青少年肌肉骨骼疼痛投诉预后的证据体系存在局限性,这些研究基于二级医疗人群或学校人群。

新发现

• 相当比例的儿童和青少年(36%)在咨询全科医生6个月后仍有活动受限的肌肉骨骼疼痛,12个月后仍有26%受影响。• 6个月时持续存在肌肉骨骼疼痛的儿童和青少年的特点是日常活动存在功能困难,所有这些都与他们的疼痛有关,其中最显著的挑战之一是背书包。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/12129871/00320053bf3d/431_2025_6217_Fig1_HTML.jpg

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