• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

患有肌肉骨骼疼痛的儿童和青少年在全科医疗就诊时的预后及生物心理社会预后因素

Prognosis and bio-psycho-social prognostic factors in children and adolescents with musculoskeletal pain consulting general practice.

作者信息

Pourbordbari Negar, Jensen Martin Bach, Olesen Jens Lykkegaard, Holden Sinead, Rathleff Michael Skovdal

机构信息

Center for General Practice at, Aalborg University, Selma Lagerløfs Vej 249, 9260, Gistrup, Denmark.

Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Frederik Bajers Vej 7D, 9200, Aalborg, Denmark.

出版信息

Eur J Pediatr. 2025 Jun 2;184(6):384. doi: 10.1007/s00431-025-06217-2.

DOI:10.1007/s00431-025-06217-2
PMID:40455265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12129871/
Abstract

UNLABELLED

To investigate the 12-months prognosis and prognostic factors of 8-19-year-olds with musculoskeletal pain in general practice. A prospective cohort was conducted in a setting of Danish general practice clinics. Participants were children and adolescents aged 8-19 years old consulting the general practitioner with self-reported musculoskeletal pain completed a questionnaire at baseline, 3-, 6-, and 12-month follow-up. No interventions were applied. The primary outcome was activity-limiting pain at 6 months, regardless of pain location. We included one hundred children and adolescents (median age 13 years interquartile range 12-16.5, 55% female) with a follow-up rate of 70% at 6 months and 67% at 12 months. The most common pain site was the knee. After 6 months, 36% reported activity-limiting pain and 42% reported multi-site pain. After 12 months, 26% reported activity-limiting pain. Children and adolescents who felt nervous (odds ratio (OR) 4.2 95% confidence interval (CI) 1.4-12.5) or tired during the day (OR 2.9 95% CI 1.1-7.7), with 1-7 days of pain episodes (OR 7.1 95% CI 1.8-28.9), who used pain medication (OR 5.4 95% CI 1.6-18.4), had difficulties falling asleep (OR 4.8 95% CI 1.7-13.9), carrying a schoolbag (OR 3.8 95% CI 1.1-13.1), or bending down to put on socks due to pain (OR 4.1 95% CI 1.3-13.2) had a higher risk of pain after 6 months.  Conclusion: One-third of adolescents consulting their GP for MSK pain continue to experience activity-limiting pain at 6 months. This highlights the need for early identification of risk factors and a biopsychosocial approach to pain management in general practice. This study was performed at the Center for General Practice at Aalborg University, Fyrkildevej 7 1st floor, 9220 Aalborg Ø, Denmark. This work was supported by the Multidisciplinary Committee (MPU) providing a grant used for compensation for the general practice clinic's time spent on recruitment [grant number ID: MPU 20-2017/date 100117].

CLINICALTRIALS

gov (Identifier NCT03678922) and link: https://clinicaltrials.gov/study/NCT03678922?term=NCT03678922&rank=1.

WHAT IS KNOWN

• Musculoskeletal pain, among other pain sites; headache and abdominal pain account for most of the recurrent painful states among children and adolescents; they may have a poorer prognosis and the MSK pain a larger impact than realized. • Many adolescents consult their GP with MSK pain, but there is a lack of data in this setting of early stage management resulting in a limitation in the current body of evidence on the prognosis of adolescent MSK pain complaints is studies based on secondary care population or school-based population.

WHAT IS NEW

• A substantial proportion of children and adolescents (36%) continue to experience activity-limiting MSK pain six months after consulting their GP, with 26% still affected after 12 months. • Children and adolescents with persistent MSK pain at six months was characterized by functional difficulties in daily activities, all linked to their pain, - one of the most notable challenges was carrying a schoolbag.

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/12129871/12b670cb39f9/431_2025_6217_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/12129871/00320053bf3d/431_2025_6217_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/12129871/2a99b0f50883/431_2025_6217_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/12129871/12b670cb39f9/431_2025_6217_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/12129871/00320053bf3d/431_2025_6217_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/12129871/2a99b0f50883/431_2025_6217_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/12129871/12b670cb39f9/431_2025_6217_Fig3_HTML.jpg
摘要

未标注

为研究8至19岁肌肉骨骼疼痛患者在全科医疗中的12个月预后及预后因素。在丹麦全科医疗诊所开展了一项前瞻性队列研究。参与者为8至19岁因自我报告的肌肉骨骼疼痛而咨询全科医生的儿童和青少年,他们在基线、3个月、6个月和12个月随访时完成了一份问卷。未实施任何干预措施。主要结局是6个月时限制活动的疼痛,无论疼痛部位如何。我们纳入了100名儿童和青少年(中位年龄13岁,四分位间距12 - 16.5岁,55%为女性),6个月时随访率为70%,12个月时为67%。最常见的疼痛部位是膝盖。6个月后,36%的人报告有活动受限疼痛,42%的人报告有多部位疼痛。12个月后,26%的人报告有活动受限疼痛。在白天感到紧张(比值比(OR)4.2,95%置信区间(CI)1.4 - 12.5)或疲倦(OR 2.9,95% CI 1.1 - 7.7)、有1 - 7天疼痛发作(OR 7.1,95% CI 1.8 - 28.9)、使用止痛药物(OR 5.4,95% CI 1.6 - 18.4)、入睡困难(OR 4.8,95% CI 1.7 - 13.9)、因疼痛背书包困难(OR 3.8,95% CI 1.1 - 13.1)或弯腰穿袜子困难(OR 4.1,95% CI 1.3 - 13.2)的儿童和青少年,6个月后疼痛风险更高。结论:因肌肉骨骼疼痛咨询全科医生的青少年中,三分之一在6个月时仍有活动受限疼痛。这凸显了在全科医疗中早期识别风险因素及采用生物心理社会方法进行疼痛管理的必要性。本研究在奥尔堡大学全科医疗中心进行,地址为丹麦奥尔堡Ø市菲基尔德韦街7号1楼,邮编9220。本研究得到多学科委员会(MPU)的支持,该委员会提供了一笔赠款,用于补偿全科医疗诊所在招募工作上花费的时间[赠款编号:MPU 20 - 2017/日期100117]。

临床试验

美国国立医学图书馆临床试验注册库(标识符NCT03678922)及链接:https://clinicaltrials.gov/study/NCT03678922?term=NCT03678922&rank=1。

已知信息

• 肌肉骨骼疼痛,在其他疼痛部位中,头痛和腹痛占儿童和青少年复发性疼痛状态的大部分;它们可能预后较差,且肌肉骨骼疼痛的影响比意识到的更大。• 许多青少年因肌肉骨骼疼痛咨询全科医生,但在这种早期管理背景下缺乏数据,导致目前关于青少年肌肉骨骼疼痛投诉预后的证据体系存在局限性,这些研究基于二级医疗人群或学校人群。

新发现

• 相当比例的儿童和青少年(36%)在咨询全科医生6个月后仍有活动受限的肌肉骨骼疼痛,12个月后仍有26%受影响。• 6个月时持续存在肌肉骨骼疼痛的儿童和青少年的特点是日常活动存在功能困难,所有这些都与他们的疼痛有关,其中最显著的挑战之一是背书包。

相似文献

1
Prognosis and bio-psycho-social prognostic factors in children and adolescents with musculoskeletal pain consulting general practice.患有肌肉骨骼疼痛的儿童和青少年在全科医疗就诊时的预后及生物心理社会预后因素
Eur J Pediatr. 2025 Jun 2;184(6):384. doi: 10.1007/s00431-025-06217-2.
2
Bio-psycho-social characteristics and impact of musculoskeletal pain in one hundred children and adolescents consulting general practice.一百名咨询全科医疗的儿童和青少年的肌肉骨骼疼痛的生物心理社会特征及影响
BMC Prim Care. 2022 Jan 25;23(1):20. doi: 10.1186/s12875-022-01628-8.
3
Stratified primary care versus non-stratified care for musculoskeletal pain: findings from the STarT MSK feasibility and pilot cluster randomized controlled trial.分层初级保健与非分层保健治疗肌肉骨骼疼痛:来自 STarT MSK 可行性和试点集群随机对照试验的结果。
BMC Fam Pract. 2020 Feb 11;21(1):30. doi: 10.1186/s12875-019-1074-9.
4
Poor prognosis of child and adolescent musculoskeletal pain: a systematic literature review.儿童和青少年肌肉骨骼疼痛预后不良:系统文献回顾。
BMJ Open. 2019 Jul 18;9(7):e024921. doi: 10.1136/bmjopen-2018-024921.
5
Pain among children and adolescents: restrictions in daily living and triggering factors.儿童和青少年的疼痛:日常生活中的限制及触发因素。
Pediatrics. 2005 Feb;115(2):e152-62. doi: 10.1542/peds.2004-0682.
6
Predictors of the transition from acute to persistent musculoskeletal pain in children and adolescents: a prospective study.儿童和青少年从急性肌肉骨骼疼痛转变为持续性疼痛的预测因素:一项前瞻性研究。
Pain. 2017 May;158(5):794-801. doi: 10.1097/j.pain.0000000000000817.
7
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.在流行地区,服用抗叶酸抗疟药物的人群中,叶酸补充剂与疟疾易感性和严重程度的关系。
Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217.
8
Baseline musculoskeletal pain and impaired sleep related to school pressure influence the development of musculoskeletal pain in N = 107 adolescents in a 5-year longitudinal study.在一项为期 5 年的纵向研究中,N=107 名青少年的基线肌肉骨骼疼痛和与学校压力相关的睡眠障碍会影响肌肉骨骼疼痛的发展。
Eur Spine J. 2020 Mar;29(3):540-548. doi: 10.1007/s00586-019-06211-x. Epub 2019 Nov 21.
9
Comorbid insomnia, psychological symptoms and widespread pain among patients suffering from musculoskeletal pain in general practice: a cross-sectional study.综合医疗机构中肌肉骨骼疼痛患者共病失眠、心理症状和广泛疼痛:一项横断面研究。
BMJ Open. 2019 Jun 29;9(6):e031971. doi: 10.1136/bmjopen-2019-031971.
10
Musculoskeletal pain in 13-year-old children: the generation R study.13 岁儿童肌肉骨骼疼痛:世代研究。
Pain. 2024 Aug 1;165(8):1806-1813. doi: 10.1097/j.pain.0000000000003182. Epub 2024 Feb 7.

本文引用的文献

1
The prevalence of chronic pain in children and adolescents: a systematic review update and meta-analysis.儿童和青少年慢性疼痛的患病率:系统评价更新与荟萃分析
Pain. 2024 Oct 1;165(10):2215-2234. doi: 10.1097/j.pain.0000000000003267. Epub 2024 May 15.
2
Bio-psycho-social characteristics and impact of musculoskeletal pain in one hundred children and adolescents consulting general practice.一百名咨询全科医疗的儿童和青少年的肌肉骨骼疼痛的生物心理社会特征及影响
BMC Prim Care. 2022 Jan 25;23(1):20. doi: 10.1186/s12875-022-01628-8.
3
[Relationship between low back pain and screen time among schoolchildren.].
[学龄儿童腰痛与屏幕使用时间之间的关系。]
Rev Esp Salud Publica. 2021 Oct 13;95:e202110132.
4
Pain medication use for musculoskeletal pain among children and adolescents: a systematic review.儿童和青少年肌肉骨骼疼痛的止痛药物使用:一项系统评价
Scand J Pain. 2021 Sep 13;21(4):653-670. doi: 10.1515/sjpain-2021-0033. Print 2021 Oct 26.
5
Delivering transformative action in paediatric pain: a Lancet Child & Adolescent Health Commission.在儿童疼痛领域采取变革性行动:《柳叶刀儿童与青少年健康》委员会
Lancet Child Adolesc Health. 2021 Jan;5(1):47-87. doi: 10.1016/S2352-4642(20)30277-7. Epub 2020 Oct 13.
6
Musculoskeletal pain distribution in 1,000 Danish schoolchildren aged 8-16 years.1000 名 8-16 岁丹麦学童的肌肉骨骼疼痛分布情况。
Chiropr Man Therap. 2020 Aug 4;28(1):45. doi: 10.1186/s12998-020-00330-9.
7
A conceptual framework for prognostic research.预后研究的概念框架。
BMC Med Res Methodol. 2020 Jun 29;20(1):172. doi: 10.1186/s12874-020-01050-7.
8
Poor prognosis of child and adolescent musculoskeletal pain: a systematic literature review.儿童和青少年肌肉骨骼疼痛预后不良:系统文献回顾。
BMJ Open. 2019 Jul 18;9(7):e024921. doi: 10.1136/bmjopen-2018-024921.
9
Do schoolbags cause back pain in children and adolescents? A systematic review.书包会导致儿童和青少年背痛吗?系统评价。
Br J Sports Med. 2018 Oct;52(19):1241-1245. doi: 10.1136/bjsports-2017-098927. Epub 2018 May 2.
10
Epidemiology of paediatric presentations with musculoskeletal problems in primary care.基层医疗中儿童肌肉骨骼问题就诊情况的流行病学
BMC Musculoskelet Disord. 2018 Feb 6;19(1):40. doi: 10.1186/s12891-018-1952-7.