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Label-free optical imaging and sensing of single nanoparticles are vital for fundamental research, disease diagnosis, and nanomaterial studies. Surface plasmon resonance microscopy (SPRM) is a label-free detection technology which is widely used in the detection of single nanoparticles. However, conventional SPRM suffers from poor spatial resolution, a limited field-of-view, system complexity, and high operating costs. In this study, we introduce a compact, low-cost, and large field-of-view chip-based plasmonic scattering microscopy (Chip-PSM). Compared with SPRM, Chip-PSM retains high detection sensitivity and in situ label-free analysis capability, while offering a larger field-of-view, an isotropic point-spread-function and higher spatial resolution. With these advantages, Chip-PSM enables detecting and imaging dielectric nanoparticles, gold nanoparticles, and biological samples. Additionally, the hygroscopic growth dynamics of aerosol nanoparticles and the chemical reactions occurring on nanocrystals are successfully characterized via Chip-PSM. We anticipate that the proposed Chip-PSM will have broad applications across many scientific fields, including physics, chemistry, and atmospheric sciences.

Large field-of-view plasmonic scattering imaging and sensing of nanoparticles with isotropic point-spread-function.

作者信息

You Xinxiang, Fan Zetao, Zhang Hongli, Xie Zhibo, Li Chengen, Gui Huaqiao, Zou Gang, Zhan Qiwen, Liu Jianguo, Liu Xu, Zhang Douguo

机构信息

Advanced Laser Technology Laboratory of Anhui Province, Department of Optics and Optical Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.

Hefei National Laboratory, University of Science and Technology of China, Hefei, Anhui, 230088, China.

出版信息

Nat Commun. 2025 Jun 2;16(1):5104. doi: 10.1038/s41467-025-60460-7.

单纳米颗粒的无标记光学成像与传感对于基础研究、疾病诊断和纳米材料研究至关重要。表面等离子体共振显微镜（SPRM）是一种无标记检测技术，广泛应用于单纳米颗粒的检测。然而，传统的SPRM存在空间分辨率差、视场有限、系统复杂和运行成本高等问题。在本研究中，我们介绍了一种基于芯片的紧凑型、低成本且大视场的等离子体散射显微镜（Chip-PSM）。与SPRM相比，Chip-PSM保留了高检测灵敏度和原位无标记分析能力，同时提供了更大的视场、各向同性的点扩散函数和更高的空间分辨率。凭借这些优势，Chip-PSM能够检测和成像介电纳米颗粒、金纳米颗粒和生物样品。此外，通过Chip-PSM成功地表征了气溶胶纳米颗粒的吸湿生长动力学以及纳米晶体上发生的化学反应。我们预计，所提出的Chip-PSM将在包括物理、化学和大气科学在内的许多科学领域具有广泛的应用。