Moreira-Soto Andres, Postigo-Hidalgo Ignacio, Tabares Ximena, Roell Yannik, Fischer Carlo, Gotuzzo Eduardo, Jaenisch Thomas, Levi José Eduardo, Lustig Yaniv, Drexler Jan Felix
Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.
Tropical Disease Research Program, School of Veterinary Medicine, Universidad Nacional, Costa Rica, Costa Rica.
Lancet Reg Health Am. 2025 May 5;46:101089. doi: 10.1016/j.lana.2025.101089. eCollection 2025 Jun.
Arboviruses impose a major public health burden in Latin America and the Caribbean due to widespread and potentially severe infections causing microcephaly and long-lasting arthralgia. Beyond canonical vector-borne transmission, the magnitude and risk factors for transfusion-transmitted infections (TTIs) are unclear. In this narrative report, we use analyses of virological data such as infection symptomatology, viremic periods, and viral loads, to argue that dengue, Oropouche, Zika, yellow fever, and Chikungunya viruses pose an under-investigated risk of TTIs. An analysis of socioeconomic data showed that blood donation rates in Latin America and the Caribbean correlated with gross domestic product (r = 0.53, = 0.0021) and health expenditure (r = 0.5, = 0.0045), highlighting that resource limitations impact blood screening. Risk maps based on vector occurrence and ecological variables showed that Central America and Northwest coastal Brazil are high-risk zones, making surveillance, vector control, vaccination, and cost-effective blood screening crucial for mitigating TTIs, including Zika and potentially Oropouche viruses in pregnant women.
虫媒病毒在拉丁美洲和加勒比地区造成了重大的公共卫生负担，因为广泛传播且可能导致严重感染，引发小头畸形和持续性关节痛。除了典型的媒介传播外，输血传播感染（TTIs）的规模和风险因素尚不清楚。在这份叙述性报告中，我们通过分析病毒学数据，如感染症状、病毒血症期和病毒载量，认为登革热、奥罗普切、寨卡、黄热病和基孔肯雅病毒构成了未得到充分研究的输血传播感染风险。对社会经济数据的分析表明，拉丁美洲和加勒比地区的献血率与国内生产总值相关（r = 0.53，P = 0.0021），与卫生支出相关（r = 0.5，P = 0.0045），这突出表明资源限制会影响血液筛查。基于媒介出现情况和生态变量的风险地图显示，中美洲和巴西西北沿海地区是高风险区域，这使得监测、媒介控制、疫苗接种和具有成本效益的血液筛查对于减轻输血传播感染至关重要，包括孕妇感染寨卡病毒以及潜在的奥罗普切病毒。
