登革热患者中使用乳酸脱氢酶作为预后标志物的观察性研究。
Observational study of using lactate dehydrogenase as prognostic marker in dengue patients.
作者信息
Kasarabada Harish, Iyengar Sreenivasa S, Singh Deependra, Kushala Praveena, Joshi S K, Dayanand K
机构信息
Graded Specialist (Internal Medicine), INHS Kalyani, Visakhapatnam, India.
Senior Advisor (Nephrology), INHS Kalyani, Visakhapatnam, India.
出版信息
Med J Armed Forces India. 2025 May-Jun;81(3):275-281. doi: 10.1016/j.mjafi.2023.07.009. Epub 2023 Sep 12.
BACKGROUND
Dengue is one of the common mosquito borne illnesses in south India and it is nearly endemic in these coastal states. In view of high incidence during monsoon season with substantial mortality, the department of Internal Medicine performed a study where serum Lactate dehydrogenase levels were used as biomarker to predict severity of dengue infection to avoid complications and mortality.
METHODS
The study was an unicentric, open labelled, observational prospective study conducted in a tertiary care hospital of the coastal region. All the patients who were serologically tested with Dengue positive status during June 2022 to December 2022 were included in the study.
RESULTS
The correlation between lactate dehydrogenase (LDH) levels at the time of presentation and severity of disease is linear in nature with Pearson's coefficient of correlation (R) 0.778. The linear correlation was statistically significant with P value < 0.01. The correlation between LDH levels at the time of presentation and platelet count at time of admission was inversely proportional with Pearson's coefficient of correlation (R) - 0.326.
CONCLUSION
The main finding of the study is that LDH levels at the time of diagnosis in dengue patients can predict complications during course of illness.
背景
登革热是印度南部常见的蚊媒疾病之一，在这些沿海邦几乎呈地方流行状态。鉴于季风季节发病率高且死亡率可观，内科部门开展了一项研究，将血清乳酸脱氢酶水平用作生物标志物来预测登革热感染的严重程度，以避免并发症和死亡。
方法
该研究是在沿海地区一家三级护理医院进行的单中心、开放标签、观察性前瞻性研究。纳入了2022年6月至2022年12月期间血清学检测登革热呈阳性的所有患者。
结果
就诊时乳酸脱氢酶（LDH）水平与疾病严重程度之间的相关性呈线性，皮尔逊相关系数（R）为0.778。线性相关性具有统计学意义，P值<0.01。就诊时LDH水平与入院时血小板计数之间的相关性呈负相关，皮尔逊相关系数（R）为 - 0.326。
结论
该研究的主要发现是登革热患者诊断时的LDH水平可预测病程中的并发症。
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