Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
College of Dentistry, University of Saskatchewan, Saskatoon, SK, Canada.
Arch Oral Biol. 2022 Dec;144:105545. doi: 10.1016/j.archoralbio.2022.105545. Epub 2022 Sep 17.
The purpose of this critical review is to assess if children and adolescents with hyposalivation are more affected by dental caries than those with normal flow rate.
A literature search was performed using keywords and MeSH terms related to hyposalivation and dental caries in the Medline/PubMed, Web of Science, Cochrane Library, Scopus, LILACS/BBO databases and in gray literature without language or date restrictions until March 2022. Observational studies that accessed the presence of dental caries in patients up to 18 years-old with hyposalivation and compared with a control group (normal salivation rate) were considered eligible. The results from search were imported to EndNote Web, where duplicates were removed followed by title/abstract and full text analysis.
A total of 12,236 non-duplicated studies were found and 14 fulfilled the criteria and were included in the present review, 9 cross-sectional and 5 cohorts. Stimulated salivary flow rates were assessed in 3644 participants, aged 3-17 years. Three cohort and three cross-sectional studies observed association between low salivary flow rates and the presence of dental caries, while the other 9 included articles did not verify this association. However, the absence of a standard criteria for the hyposalivation classification in young patients was observed and brough light to this important limitation among the studies.
The salivary flow rate estimation for caries risk assessment must be the target of further studies to make possible and reliable, homogeneous, and unbiasedly assessment of the association between hyposalivation and dental caries in young patients.
本综述旨在评估唾液分泌减少的儿童和青少年是否比唾液流量正常的儿童和青少年更容易受到龋齿的影响。
使用与唾液分泌减少和龋齿相关的关键词和 MeSH 术语，在 Medline/PubMed、Web of Science、Cochrane 图书馆、Scopus、LILACS/BBO 数据库和灰色文献中进行了文献检索，无语言或日期限制，检索时间截至 2022 年 3 月。符合条件的研究是指评估了唾液分泌减少的 18 岁以下患者龋齿存在情况，并与对照组（正常唾液流速）进行比较的观察性研究。从搜索结果中导入 EndNote Web，去除重复项，然后进行标题/摘要和全文分析。
共发现 12236 篇非重复研究，其中 14 篇符合标准并纳入本综述，包括 9 项横断面研究和 5 项队列研究。在 3644 名年龄为 3-17 岁的参与者中评估了刺激唾液流速。三项队列研究和三项横断面研究观察到低唾液流速与龋齿存在之间存在关联，而其他 9 项纳入的研究未证实这种关联。然而，在年轻患者中，唾液分泌减少的分类标准缺乏一致性，这是研究中的一个重要局限性。
为了使评估唾液流量减少与龋齿之间的相关性成为可能，并进行可靠、同质且无偏倚的评估，必须针对唾液流量评估进行进一步研究。
