Santana Lucas Alves da Mota, Oliveira Michelly Kierkegaard Campos de, Carvalho Maria Vitória Conceição, Moura Pedro Henrique Macedo, Barreto Marina Dos Santos, Santos Marcos Antônio Lima Dos, Santos Pedro Lima Dos, Correia Dalmo, Silva Virgínia Kelma Dos Santos, Gopalsamy Rajiv Gandhi, Trento Cleverson Luciano, Borges Lysandro Pinto, Takeshita Wilton Mitsunari
Universidade Federal de Sergipe, Departmento de Odontologia, Aracaju, SE, Brasil.
Universidade Tiradentes, Departamento de Odontologia, Aracaju, SE, Brasil.
Rev Soc Bras Med Trop. 2025 Jun 2;58:e008042025. doi: 10.1590/0037-8682-0008-2025. eCollection 2025.
The wide distribution of angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) in oral tissues, especially in the salivary glands, which are natural reservoirs of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), contributes to the classification of the oral cavity as a potential target for the development of lesions. Despite the effective response produced by next-generation immunizers, the possibility of immune escape by new lineages of SARS-CoV-2 cannot be refuted. Therefore, we describe here the occurrence of cytogenetic alterations in orally exfoliated cells of immunized individuals and, based on the literature review, call attention to the need to monitor these cases in the post-pandemic period.
血管紧张素转换酶2（ACE2）和跨膜蛋白酶丝氨酸2（TMPRSS2）在口腔组织中广泛分布，尤其是在唾液腺中，而唾液腺是严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的天然储存库，这使得口腔被归类为病变发展的潜在靶点。尽管新一代免疫制剂产生了有效的反应，但SARS-CoV-2新谱系免疫逃逸的可能性无法被排除。因此，我们在此描述了免疫个体口腔脱落细胞中细胞遗传学改变的发生情况，并基于文献综述，呼吁关注在大流行后时期监测这些病例的必要性。
