口腔黏膜细胞细胞遗传学生物监测在 COVID-19 患者中的应用：初步研究结果。
Cytogenetic Biomonitoring in Buccal Mucosa Cells of COVID-19 Patients: Preliminary Findings.
机构信息
Department of Biosciences, Institute of Health and Society, Universidade Federal de São Paulo (UNIFESP), Santos, SP, Brazil.
Department of Biosciences, Institute of Health and Society, Universidade Federal de São Paulo (UNIFESP), Santos, SP, Brazil
出版信息
In Vivo. 2021 Nov-Dec;35(6):3495-3499. doi: 10.21873/invivo.12651.
BACKGROUND/AIM: COVID-19 may lead to progressive respiratory failure as a consequence of alveolar damage, resulting in death. The aim of this study was to evaluate cytogenetic damage in oral cells of COVID-19 patients by micronucleus assay.
PATIENTS AND METHODS
A total of 11 COVID-19 patients aged 40.7±9.3 years (5 men and 6 women) were included in this study. For the control group, a total of 15 participants not infected with SARS-CoV-2 virus were included. The mean age was 41.6±6.2 years (5 men and 10 women).
RESULTS
The results showed statistically significant differences (p<0.05) in micronucleated buccal mucosa cells of COVID-19 patients. In addittion, a statistically significant increase in karyolysis and karrhyorexis (p<0.05) was observed in COVID-19 patients compared to control.
CONCLUSION
SARS-CoV-2 virus can induce mutagenesis and cytotoxicity in oral cells.
背景/目的：COVID-19 可能会导致肺泡损伤导致进行性呼吸衰竭，从而导致死亡。本研究旨在通过微核试验评估 COVID-19 患者口腔细胞的细胞遗传学损伤。
患者和方法
本研究共纳入 11 名年龄为 40.7±9.3 岁（5 名男性和 6 名女性）的 COVID-19 患者。对照组共纳入 15 名未感染 SARS-CoV-2 病毒的参与者。平均年龄为 41.6±6.2 岁（5 名男性和 10 名女性）。
结果
结果显示 COVID-19 患者的口腔黏膜细胞微核率存在统计学显著差异（p<0.05）。此外，与对照组相比，COVID-19 患者的核溶解和核碎裂明显增加（p<0.05）。
结论
SARS-CoV-2 病毒可引起口腔细胞的突变和细胞毒性。
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