细胞死亡机制涉及 SARS-CoV-2 引起的细胞损伤。
Cell death mechanisms involved in cell injury caused by SARS-CoV-2.
机构信息
Research Center for Therapeutic Innovation Suely Galdino, Federal University of Pernambuco, Recife, Brazil.
Universidade Federal Rural de Pernambuco, Recife, Brazil.
出版信息
Rev Med Virol. 2022 May;32(3):e2292. doi: 10.1002/rmv.2292. Epub 2021 Sep 30.
Abstract
Coronavirus disease 2019 (Covid-19) is an emerging novel respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that rapidly spread worldwide. In addition to lung injury, Covid-19 patients may develop extrapulmonary symptoms, including cardiac, liver, kidney, digestive tract, and neurological injuries. Angiotensin converting enzyme 2 is the major receptor for the entry of SARS-CoV-2 into host cells. The specific mechanisms that lead to cell death in different tissues during infection by SARS-CoV-2 remains unknown. Based on data of the previous human coronavirus SARS-CoV together with information about SARS-CoV-2, this review provides a summary of the mechanisms involved in cell death, including apoptosis, autophagy, and necrosis, provoked by severe acute respiratory syndrome coronavirus.
摘要
新型冠状病毒病（COVID-19）是一种由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的新发呼吸道传染病，在全球迅速蔓延。除肺部损伤外，COVID-19 患者还可能出现肺外症状，包括心脏、肝脏、肾脏、消化道和神经系统损伤。血管紧张素转换酶 2 是 SARS-CoV-2 进入宿主细胞的主要受体。SARS-CoV-2 感染导致不同组织细胞死亡的具体机制尚不清楚。基于之前人类冠状病毒 SARS-CoV 的数据以及关于 SARS-CoV-2 的信息，本综述总结了严重急性呼吸综合征冠状病毒引起的细胞死亡机制，包括凋亡、自噬和坏死。
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Cell Death Discov. 2021 Mar 1;7(1):43. doi: 10.1038/s41420-021-00428-w.
2
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Front Chem. 2020 Nov 5;8:592289. doi: 10.3389/fchem.2020.592289. eCollection 2020.
3
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J Exp Med. 2021 Mar 1;218(3). doi: 10.1084/jem.20201707.
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5
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