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Fluorescence-Activated Cell Sorting Depletes Macrophages and Triggers Inflammation in the Single-Cell Immune Landscape of Human Atherosclerosis.

作者信息

Case Ayden G, O'Brien James W, Charlier Fiona T W, Al-Hadithi Ali B A K, Chowdhury Mohammed M, Newland Stephen A, Huang Zixuan, Basatemur Gemma, Zhao Xiaohui, Awopetu Ayoola I, Boyle Jonathan R, Evans Nicholas R, Mallat Ziad, Zhao Tian X

机构信息

Department of Medicine (A.G.C., J.W.O., F.T.W.C., A.B.A.K.A.-H., S.A.N., Z.H., G.B., X.Z., Z.M., T.X.Z.), University of Cambridge, United Kingdom.

National Heart, Lung, and Blood Institute, National Institutes of Health (NIH), Complement and Inflammation Research Section, Bethesda, MD (A.G.C.).

出版信息

Arterioscler Thromb Vasc Biol. 2025 Jul;45(7):1340-1342. doi: 10.1161/ATVBAHA.125.322856. Epub 2025 Jun 5.

DOI:10.1161/ATVBAHA.125.322856
PMID:40469035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12188805/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6bc/12188805/c6429a72f673/atv-45-1340-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6bc/12188805/c6429a72f673/atv-45-1340-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6bc/12188805/c6429a72f673/atv-45-1340-g001.jpg

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本文引用的文献

1
Cross-species single-cell RNA sequencing reveals divergent phenotypes and activation states of adaptive immunity in human carotid and experimental murine atherosclerosis.跨物种单细胞 RNA 测序揭示了人类颈动脉粥样硬化和实验性小鼠动脉粥样硬化中适应性免疫的不同表型和激活状态。
Cardiovasc Res. 2024 Nov 25;120(14):1713-1726. doi: 10.1093/cvr/cvae154.
2
High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis.人类颈动脉粥样硬化的高维单细胞多模态图谱
Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):930-945. doi: 10.1161/ATVBAHA.123.320524. Epub 2024 Feb 22.
3
Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis increasing the risk of cerebrovascular complications.
在人类动脉粥样硬化中，脂质相关巨噬细胞转变为炎症状态，增加了脑血管并发症的风险。
Nat Cardiovasc Res. 2023 Jun 26;2(7):656-672. doi: 10.1038/s44161-023-00295-x.
4
Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics.单细胞转录组学解析人动脉粥样硬化斑块的微观解剖结构。
Circ Res. 2020 Nov 6;127(11):1437-1455. doi: 10.1161/CIRCRESAHA.120.316770. Epub 2020 Sep 28.