Hughes M B, Lucchesi J C
Science. 1977 Jun 3;196(4294):1114-5. doi: 10.1126/science.404711.
While a null activity mutant allele of the structural gene for 6-phosphogluconate dehydrogenase in Drosophila melanogaster is lethal, a similar mutation for glucose-6-phosphate dehydrogenase is not. Double mutant combinations lacking both enzyme activities, obtained either by recombination or by mutagen treatment of a chromosome bearing the lethal allele, result in a restoration of viability. The indispensability of the pentose phosphate shunt in Drosophila appears to depend upon the specific position of the block within the pathway.
虽然果蝇中6-磷酸葡萄糖酸脱氢酶结构基因的无活性突变等位基因是致死的，但葡萄糖-6-磷酸脱氢酶的类似突变却不是。通过重组或对携带致死等位基因的染色体进行诱变处理获得的缺乏这两种酶活性的双突变组合，会导致活力恢复。果蝇中磷酸戊糖途径的不可或缺性似乎取决于该途径中阻断的具体位置。
