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通过饮食挽救黑腹果蝇中6-磷酸葡萄糖酸脱氢酶致死性“无效”活性等位基因的作用

Dietary rescue of a lethal "null" activity allele of 6-phosphogluconate dehydrogenase in Drosophila melanogaster.

作者信息

Hughes M B, Lucchesi J C

出版信息

Biochem Genet. 1978 Jun;16(5-6):469-75. doi: 10.1007/BF00484212.

DOI:10.1007/BF00484212
PMID:104708
Abstract

The genetic rescue of Pgdn lethal alleles, accomplished by combining them with mutations lacking glucose-6-phosphate dehydrogenase activity, has led to the hypothesis that Pgdn lethality may be due to the accumulation of 6-phosphogluconate. In this article we report the rescue of Pgdn/Y males by dietary supplements (fructose and linolenate) designed to minimize 6-phosphogluconate production.

摘要

通过将Pgdn致死等位基因与缺乏葡萄糖-6-磷酸脱氢酶活性的突变相结合来实现的对Pgdn致死等位基因的基因拯救，引发了这样一种假说，即Pgdn致死性可能是由于6-磷酸葡萄糖酸的积累所致。在本文中，我们报告了通过旨在尽量减少6-磷酸葡萄糖酸产生的膳食补充剂（果糖和亚麻酸）对Pgdn/Y雄性小鼠的拯救。

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Dietary rescue of a lethal "null" activity allele of 6-phosphogluconate dehydrogenase in Drosophila melanogaster.通过饮食挽救黑腹果蝇中6-磷酸葡萄糖酸脱氢酶致死性“无效”活性等位基因的作用
Biochem Genet. 1978 Jun;16(5-6):469-75. doi: 10.1007/BF00484212.
2
Genetic rescue of a lethal "null" activity allele of 6-phosphogluconate dehydrogenase in Drosophila melanogaster.黑腹果蝇中6-磷酸葡萄糖酸脱氢酶致死性“无效”活性等位基因的基因拯救
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Investigations on the organization of genetic loci in Drosophila melanogaster: lethal mutations affecting 6-phosphogluconate dehydrogenase and their suppression.黑腹果蝇基因位点组织的研究：影响6-磷酸葡萄糖酸脱氢酶的致死突变及其抑制作用。
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The utilization of sugars and other substances by Drosophila.果蝇对糖类及其他物质的利用
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Role of the pentose phosphate pathway in metabolism of Drosophila melanogaster elucidated by mutations affecting glucose 6-phosphate and 6-phosphogluconate dehydrogenases.通过影响葡萄糖6 - 磷酸脱氢酶和6 - 磷酸葡萄糖酸脱氢酶的突变阐明戊糖磷酸途径在黑腹果蝇代谢中的作用。
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Enzyme patterns in D. melanogaster imaginal discs: distribution of glucose-6-phosphate and 6-phosphogluconate dehydrogenase.黑腹果蝇成虫盘的酶模式：葡萄糖-6-磷酸脱氢酶和6-磷酸葡萄糖酸脱氢酶的分布
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The effect of DDT on the polymorphism at the G6pd and Pgd loci in Drosophila melanogaster.滴滴涕对黑腹果蝇G6pd和Pgd基因座多态性的影响。
Genetics. 1983 Mar;103(3):447-64. doi: 10.1093/genetics/103.3.447.
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A genetic and molecular analysis of P-induced mutations at the glucose-6-phosphate dehydrogenase locus in Drosophila melanogaster.果蝇葡萄糖-6-磷酸脱氢酶基因座上由磷诱导的突变的遗传与分子分析。
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Relationship of the oxidative pentose shunt pathway to lipid synthesis in Drosophila melanogaster.黑腹果蝇中氧化戊糖支路途径与脂质合成的关系。
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Fine genetic structure of the 2D3-2F5 region of the X-chromosome of Drosophila melanogaster.黑腹果蝇X染色体2D3 - 2F5区域的精细遗传结构
Mol Gen Genet. 1975 Dec 1;141(3):269-75. doi: 10.1007/BF00341805.
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Lethal effects of low and "null" activity alleles of 6-phosphogluconate dehydrogenase in Drosophila melanogaster.黑腹果蝇中6-磷酸葡萄糖酸脱氢酶低活性和“无活性”等位基因的致死效应
Genetics. 1975 Mar;79(3):451-7. doi: 10.1093/genetics/79.3.451.
6
Genetic rescue of a lethal "null" activity allele of 6-phosphogluconate dehydrogenase in Drosophila melanogaster.黑腹果蝇中6-磷酸葡萄糖酸脱氢酶致死性“无效”活性等位基因的基因拯救
Science. 1977 Jun 3;196(4294):1114-5. doi: 10.1126/science.404711.
7
Regulation of the oxidative NADP-enzyme tissue levels in Drosophila melanogaster. I. Modulation by dietary carbohydrate and lipid.黑腹果蝇中氧化型烟酰胺腺嘌呤二核苷酸磷酸（NADP）酶组织水平的调节。I. 饮食中碳水化合物和脂质的调节作用
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