黑腹果蝇中6-磷酸葡萄糖酸脱氢酶低活性和“无活性”等位基因的致死效应
Lethal effects of low and "null" activity alleles of 6-phosphogluconate dehydrogenase in Drosophila melanogaster.
作者信息
Bewley G C, Lucchesi J G
出版信息
Genetics. 1975 Mar;79(3):451-7. doi: 10.1093/genetics/79.3.451.
Abstract
EMS-induced "null" and low activity alleles for 6-phosphogluconate dehydrogenase were characterized with respect to enzymatic activity, relative viability, fertility, and the effective lethal phase. It was determined that flies hemizygous and homozygous for the low activity allele, Pgd minus, possessed a depressed development rate, diminished viability, and loss of female female fertility. Heterozygotes for Pgd minus and a deficiency for Pgd+ were lethal. The "null" activity allele demonstrated a lethal phenotype in both the hemizygous and homozygous condition. The effective lethal phase for the "null" allele occurs during late embryonic development (20-22 hr).
摘要
对经EMS诱导产生的6-磷酸葡萄糖酸脱氢酶的“无效”和低活性等位基因，在酶活性、相对活力、育性及有效致死期方面进行了表征。结果表明，低活性等位基因Pgd减的半合子和纯合子果蝇，其发育速率降低、活力减弱且雌性育性丧失。Pgd减的杂合子与Pgd + 的缺失型为致死型。“无效”活性等位基因在半合子和纯合子状态下均表现出致死表型。“无效”等位基因的有效致死期出现在胚胎发育后期（20 - 22小时）。
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