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Extensive epigenomic dysregulation is a hallmark of homologous recombination deficiency in triple-negative breast cancer.广泛的表观基因组失调是三阴性乳腺癌中同源重组缺陷的一个标志。
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本文引用的文献

1
Extensive epigenomic dysregulation is a hallmark of homologous recombination deficiency in triple-negative breast cancer.广泛的表观基因组失调是三阴性乳腺癌中同源重组缺陷的一个标志。
Int J Cancer. 2025 Mar 15;156(6):1191-1202. doi: 10.1002/ijc.35274. Epub 2024 Dec 5.
2
Prenatal BRCA1 epimutations contribute significantly to triple-negative breast cancer development.产前 BRCA1 表观突变对三阴性乳腺癌的发展有重要贡献。
Genome Med. 2023 Dec 6;15(1):104. doi: 10.1186/s13073-023-01262-8.
3
Epigenome-wide association studies: current knowledge, strategies and recommendations.全基因组表观遗传关联研究：当前的知识、策略和建议。
Clin Epigenetics. 2021 Dec 4;13(1):214. doi: 10.1186/s13148-021-01200-8.
4
Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes.多组学分析鉴定三阴性乳腺癌亚型的治疗脆弱性。
Nat Commun. 2021 Nov 1;12(1):6276. doi: 10.1038/s41467-021-26502-6.
5
Molecular and epigenetic profiles of BRCA1-like hormone-receptor-positive breast tumors identified with development and application of a copy-number-based classifier.基于拷贝数的分类器的开发和应用鉴定出的具有 BRCA1 样激素受体阳性的乳腺癌的分子和表观遗传特征。
Breast Cancer Res. 2019 Jan 25;21(1):14. doi: 10.1186/s13058-018-1090-z.
6
Pan-Cancer Analysis Reveals Differential Susceptibility of Bidirectional Gene Promoters to DNA Methylation, Somatic Mutations, and Copy Number Alterations.泛癌症分析揭示双向基因启动子对 DNA 甲基化、体细胞突变和拷贝数改变的不同敏感性。
Int J Mol Sci. 2018 Aug 5;19(8):2296. doi: 10.3390/ijms19082296.
7
Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial.BRCA1/2 突变型和三阴性乳腺癌 BRCA 样亚组中的卡铂：TNT 试验。
Nat Med. 2018 May;24(5):628-637. doi: 10.1038/s41591-018-0009-7. Epub 2018 Apr 30.
8
HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures.HRDetect是一种基于突变特征的BRCA1和BRCA2缺陷预测指标。
Nat Med. 2017 Apr;23(4):517-525. doi: 10.1038/nm.4292. Epub 2017 Mar 13.
9
Statistical challenges in analyzing methylation and long-range chromosomal interaction data.分析甲基化和长程染色体相互作用数据时的统计学挑战。
Stat Biosci. 2016 Oct;8(2):284-309. doi: 10.1007/s12561-016-9145-0. Epub 2016 Mar 7.
10
Quantitative copy number analysis by Multiplex Ligation-dependent Probe Amplification (MLPA) of BRCA1-associated breast cancer regions identifies BRCAness.通过多重连接依赖性探针扩增（MLPA）对 BRCA1 相关乳腺癌区域进行定量拷贝数分析可鉴定 BRCA 样特征。
Breast Cancer Res. 2011 Oct 27;13(5):R107. doi: 10.1186/bcr3049.

Reply to: "Comments on the paper 'Extensive epigenomic dysregulation is a hallmark of homologous recombination deficiency in triple-negative breast cancer' by Y. Chen et al.".

作者信息

Chen Youdinghuan, Salas Lucas A, Marotti Jonathan D, Jenkins Nicole P, Cheng Chao, Miller Todd W, Kettenbach Arminja N, Christensen Brock C

机构信息

Department of Molecular and Systems Biology, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA.

Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA.

出版信息

Int J Cancer. 2025 Aug 1;157(3):590-591. doi: 10.1002/ijc.35434. Epub 2025 Apr 18.

DOI:10.1002/ijc.35434
PMID:40474572
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12143072/
Abstract
摘要