Du Yi-Mei, Zeng Jing, Li Meng, Wang Yang-Bin, Wu Yan, Qi Rui-Qun, Gao Xing-Hua, Chen Hong-Duo
Department of Dermatology, The First Hospital of China Medical University, Shenyang, China.
NHC Key Laboratory of Immunodermatology (China Medical University), Shenyang, China.
J Cosmet Dermatol. 2021 Dec;20(12):3880-3888. doi: 10.1111/jocd.14569. Epub 2021 Oct 31.
To evaluate the efficacy and safety of resveratrol combined with ablative fractional CO laser system (AFL) treating skin photoaging.
Thirty-two subjects were assigned to the treatment group (TG) or the control group (CG), respectively, applied test product (resveratrol essence) or control product twice daily for 6 months. Each subject was given an AFL treatment or no laser treatment on left or right side of the face randomly. Subjective evaluations by investigators and subjects themselves were conducted after treatment. Melanin index, erythema index, and cuticle moisture content were conducted at baseline and after treatments. Adverse events (AEs) were evaluated during the study period.
All subjects in TG achieved improvements of their photoaging signs compared to pre-treatment both the laser side and the non-laser side at 6 months (p < 0.05). On the laser side, TG produced a better improvement than CG at 6 months (p < 0.05). On the laser side, the difference values of MI in TG at the 2 months after enrollment (M2), M3, and M4 were more obvious than those in CG (p < 0.05). On the non-laser side, the difference values of MI in TG at M3, M4, M5, and M6 were more obvious than those of CG (p < 0.05). Subjects in TG were more likely to have tingling and had a faster subsidence of erythema mild edema, and pigmentation induced by AFL compared to CG.
The resveratrol can improve photoaging alone and add an efficacy to the AFL treatment and subside the AEs induced by AFL.
评估白藜芦醇联合非剥脱性铒激光系统（AFL）治疗皮肤光老化的疗效和安全性。
32名受试者分别被分配至治疗组（TG）或对照组（CG），分别每日两次涂抹受试产品（白藜芦醇精华液）或对照产品，持续6个月。每位受试者面部的左侧或右侧被随机给予一次AFL治疗或不进行激光治疗。治疗后由研究者和受试者本人进行主观评估。在基线期和治疗后测量黑色素指数、红斑指数和角质层含水量。在研究期间评估不良事件（AE）。
与治疗前相比，TG组所有受试者在6个月时激光侧和非激光侧的光老化迹象均有改善（p<0.05）。在激光侧，TG组在6个月时的改善情况优于CG组（p<0.05）。在激光侧，TG组在入组后第2个月（M2）、M3和M4时的MI差值比CG组更明显（p<0.05）。在非激光侧，TG组在M3、M4、M5和M6时的MI差值比CG组更明显（p<0.05）。与CG组相比，TG组的受试者更易出现刺痛感，且AFL引起的红斑、轻度水肿和色素沉着消退更快。
白藜芦醇可单独改善光老化，增强AFL治疗的疗效，并减轻AFL引起的不良事件。
