食物抗原引发的细胞破坏机制：III. 酮替芬对直接及抗体依赖性变应性自身细胞毒性（ACT）的抑制作用
Cytodestructive mechanisms provoked by food antigens: III. Inhibition of direct and antibody-dependent allergic autocytotoxicity (ACT) by ketotifen.
作者信息
Podleski W K, Panaszek B A, McDonald C, Schmidt J L, Burns R B
出版信息
Pediatr Pharmacol (New York). 1985;5(2):97-105.
In vitro challenge of peripheral white blood cells (WBC) from 15 food sensitive individuals and 16 asymptomatic controls was studied in allergic autocytotoxicity (ACT) assay using extracts of cow's milk, corn, and wheat. The observed disintegration of the WBC in the direct and antibody-dependent ACT was inhibited by ketotifen in a linear, dose-dependent manner. Therefore, our data demonstrate that the ACT response is associated with anaphylactic injury which is prevented by pretreatment with ketotifen, in vitro.
在过敏性自身细胞毒性（ACT）试验中，使用牛奶、玉米和小麦提取物，对15名食物敏感个体和16名无症状对照者的外周白细胞（WBC）进行了体外刺激研究。在直接ACT和抗体依赖性ACT中观察到的白细胞解体受到酮替芬的抑制，呈线性剂量依赖性。因此，我们的数据表明，ACT反应与过敏性损伤有关，在体外，酮替芬预处理可预防这种损伤。
Zotero 插件