Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, MB, Canada.
Centre on Aging, University of Manitoba, Winnipeg, Canada.
Eur J Appl Physiol. 2018 Dec;118(12):2679-2686. doi: 10.1007/s00421-018-3995-8. Epub 2018 Sep 22.
Blood flow restricted resistance exercise (BFR-RE) is an emerging hypertrophy training modality. A complete profile of its mechanisms of action has yet to be elucidated. Cytokines are universal intercellular messengers. Recent research has implicated certain cytokines (termed "myokines") in skeletal muscle hypertrophy pathways; however, little research has been conducted on the systemic myokine response to BFR-RE as potential hypertrophic biomarkers. Therefore, this project was conducted to determine any differences in the systemic myokine response between BFR-RE and control conditions.
The appearance of systemic myokines interleukin-6 (IL-6), interleukin-15 (IL-15), and decorin were measured following acute bouts of low-load resistance exercise, BFR-RE, and high-load resistance exercise in physically active young males to determine if BFR-RE modifies the exercise-induced systemic myokine response.
No measurable levels of IL-6 were observed during the project. No significant effects were observed for IL-15. A significant time (11.91% increase pre to post exercise; p < 0.05) but no condition or condition by time effect was observed for decorin.
These findings suggest that BFR-RE does not modify the systemic myokine appearance of IL-6, IL-15, or decorin when compared to control conditions.
血流限制型抗阻运动（BFR-RE）是一种新兴的肌肉肥大训练方式。其作用机制尚未完全阐明。细胞因子是通用的细胞间信使。最近的研究表明，某些细胞因子（称为“肌因子”）参与了骨骼肌肥大途径；然而，关于 BFR-RE 对系统性肌因子反应作为潜在的肥大生物标志物的研究还很少。因此，本研究旨在确定 BFR-RE 与对照条件下系统性肌因子反应之间是否存在差异。
在身体活跃的年轻男性中，测量单次低负荷抗阻运动、BFR-RE 和高负荷抗阻运动后系统性肌因子白细胞介素-6 (IL-6)、白细胞介素-15 (IL-15) 和饰胶蛋白的全身出现情况，以确定 BFR-RE 是否改变运动引起的全身肌因子反应。
在整个研究过程中，均未观察到可测量水平的 IL-6。IL-15 未观察到显著影响。饰胶蛋白观察到显著的时间变化（运动前后增加 11.91%；p<0.05），但无条件或条件与时间的相互作用。
与对照条件相比，BFR-RE 不会改变 IL-6、IL-15 或饰胶蛋白的系统性肌因子出现。
