Cordingley Dean M, Anderson Judy E, Cornish Stephen M
Applied Health Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Pan Am Clinic Foundation, 75 Poseidon Bay, Winnipeg, MB R3M 3E4, Canada.
Muscles. 2024 Jul 1;3(3):202-211. doi: 10.3390/muscles3030018.
Myokines released by exercise are identified as factors that can influence a person's health and wellbeing. While myokine secretion in response to an acute bout of endurance and resistance-type exercise has been examined, the influence of resistance-exercise training on myokines at rest is less well established. Therefore, this study was designed to evaluate a panel of myokines at rest following a 12-week resistance-exercise training program in younger and older males. Participants (n = 15) completed a 12-week progressive resistance-exercise training program supervised by a certified fitness professional. The training protocol targeted all major muscle groups of the upper and lower body. Resting blood samples were collected before and after completion of the training program to determine concentrations of apelin, fibroblast growth factor-21 (FGF-21), interleukin (IL)-4, IL-6, IL-7, IL-15, leukemia inhibitory factor (LIF), and irisin. Two-way repeated ANOVAs were used to compare variables between time-points and age groups. There was a main effect of time found for apelin ( = 0.003) and IL-15 ( < 0.001), while no main effects for group or time were found for the other myokines (all > 0.05). Age group × training status interactions were found for IL-6 ( = 0.04) and irisin ( = 0.014) without pairwise differences for IL-6 ( > 0.05), and younger males had higher concentrations of irisin compared to older males post-training ( = 0.036). Overall, the 12-week resistance-exercise training program significantly increased apelin and IL-15 over time but did not change the other resting myokine concentrations for the younger or older males. However, the higher concentration of irisin in younger versus older males post-training suggests a potential explanation for the anabolic resistance observed with aging.
运动释放的肌动蛋白被认为是能够影响人体健康和幸福的因素。虽然已经研究了急性耐力和阻力型运动后肌动蛋白的分泌情况，但阻力训练对静息状态下肌动蛋白的影响尚不明确。因此，本研究旨在评估年轻和老年男性在进行为期12周的阻力训练计划后静息状态下的一组肌动蛋白。参与者（n = 15）在认证健身专业人员的监督下完成了为期12周的渐进式阻力训练计划。训练方案针对上半身和下半身的所有主要肌肉群。在训练计划完成前后采集静息血样，以测定apelin、成纤维细胞生长因子-21（FGF-21）、白细胞介素（IL）-4、IL-6、IL-7、IL-15、白血病抑制因子（LIF）和鸢尾素的浓度。使用双向重复方差分析比较时间点和年龄组之间的变量。发现apelin（ = 0.003）和IL-15（ < 0.001）有时间主效应，而其他肌动蛋白未发现组或时间的主效应（所有 > 0.05）。发现IL-6（ = 0.04）和鸢尾素（ = 0.014）存在年龄组×训练状态交互作用，IL-6无成对差异（ > 0.05），训练后年轻男性的鸢尾素浓度高于老年男性（ = 0.036）。总体而言，为期12周的阻力训练计划随时间显著增加了apelin和IL-15，但年轻或老年男性的其他静息肌动蛋白浓度没有变化。然而，训练后年轻男性与老年男性相比鸢尾素浓度较高，这为衰老过程中观察到的合成代谢抵抗提供了一个潜在解释。
