Liu Ting-Ting, Zhang Xiao-Jie, Chen Kai, Yan Zhi-Gang, Zhang Jia-Bo
Hangzhou Dianzi University, Hangzhou, Zhejiang, China.
Lasers Med Sci. 2025 Jun 9;40(1):263. doi: 10.1007/s10103-025-04513-9.
This article introduces a novel approach to transdermal drug delivery using a laser-driven microjet device. By employing laser ablation on thin metal foils, plasma jets are generated, which in turn induce deformation in a silicone membrane, resulting in sufficient pressure to propel liquid jets for transdermal drug delivery. Aluminum and copper foils, which are closely adhered to the silicone membrane, undergo laser treatment with varying energy densities using a nanosecond Nd: YAG laser. The real-time measurement of material deformation is conducted using displacement sensors. A comparative analysis of the experimental data of different metal foils subjected to laser impacts of varying energy densities was performed. Additionally, the impacts of plasma shock waves generated by different energy lasers on different metal foils are compared. Finite element simulation analysis of metal foil deformation under different energy laser impacts was conducted using ABAQUS simulation software. The research findings indicate a correlation between the experimental and simulation results. Under similar laser impact energies, aluminum foil exhibits more pronounced deformation than copper foil, with a maximum deformation approximately 1.6 to 1.73 times that of copper foil, and aluminum foil demonstrates a relatively higher rate of deformation growth. Moreover, as the laser impact energy increased, the deformation velocity of both the aluminum and copper foils gradually increased, with the aluminum foil exhibiting a higher rate of acceleration. Employing aluminum foil with more evident deformation in the drug injection system, high-speed video cameras capture the microjet streams generated by laser ablation-driven aluminum foil at a frame rate of 1000 kfps (1-millisecond frame interval) under shadow optical settings. The velocity of the microjet streams was measured from visual images, reaching 100 m/s at 55.56 µs and peaking at 105 m/s at 129.64 µs, thereby enhancing the drug delivery efficiency. This study presents a novel approach and methodology for the microjet injection of drugs utilizing laser ablation technology, offering significant theoretical and practical implications.
本文介绍了一种使用激光驱动微射流装置进行经皮给药的新方法。通过对薄金属箔进行激光烧蚀，产生等离子体射流，进而使硅膜产生变形，从而产生足够的压力来推动液体射流进行经皮给药。紧密附着在硅膜上的铝箔和铜箔，使用纳秒级钕:钇铝石榴石激光以不同的能量密度进行激光处理。使用位移传感器对材料变形进行实时测量。对不同能量密度激光冲击下不同金属箔的实验数据进行了对比分析。此外，还比较了不同能量激光产生的等离子体冲击波对不同金属箔的影响。使用ABAQUS模拟软件对不同能量激光冲击下金属箔的变形进行了有限元模拟分析。研究结果表明实验结果与模拟结果之间存在相关性。在相似的激光冲击能量下，铝箔比铜箔表现出更明显的变形，最大变形约为铜箔的1.6至1.73倍，并且铝箔的变形增长率相对较高。此外，随着激光冲击能量的增加，铝箔和铜箔的变形速度都逐渐增加，铝箔的加速度更高。在药物注射系统中采用变形更明显的铝箔，高速摄像机在阴影光学设置下以1000 kfps（1毫秒帧间隔）的帧率捕捉激光烧蚀驱动铝箔产生的微射流。从视觉图像中测量微射流的速度，在55.56微秒时达到100米/秒，并在129.64微秒时达到峰值105米/秒，从而提高了药物递送效率。本研究提出了一种利用激光烧蚀技术进行药物微射流注射的新方法和新方法，具有重要的理论和实际意义。
