Afzal Sajida, Khan Siraj, Ammarullah Muhammad Imam
Department of Biomedical Engineering (Medicine), Shenzhen University, Shenzhen, 518060, Guangdong, China.
Shenzhen Hospital, Shenzhen, Guangdong, China.
Open Med (Wars). 2025 Jun 3;20(1):20241092. doi: 10.1515/med-2024-1092. eCollection 2025.
This study comprehensively analyzes the pharmacological effects of ethanolic extract of (EEAT) on various physiological parameters in mice.
The research aimed to quantify flavonoid and phenol contents across different extraction methods, with a focus on the superior efficacy of the ethanolic extract.
assays were conducted to assess the antioxidant activity of EEAT, revealing dose-dependent effects and significant inhibition percentages.
EEAT exhibited notable analgesic effects in the writhing response test, particularly at 200 mg/kg, indicating its potential as a natural analgesic. Additionally, its anti-inflammatory effects were complex and dose-dependent in a carrageenan-induced paw edema model. The extract also showed significant changes in body temperature regulation following Brewer's yeast-induced fever, revealing a distinct pattern of initial hypothermia followed by gradual re-elevation. Furthermore, EEAT demonstrated regulatory effects on gastrointestinal motility, with higher doses enhancing intestinal transit in charcoal meal tests.
This study highlights the pharmacological potential of EEAT as a natural therapeutic agent for antioxidant, analgesic, anti-inflammatory, and gastrointestinal regulation, warranting further investigation into its mechanisms of action and therapeutic applications.
本研究全面分析了[植物名称]乙醇提取物（EEAT）对小鼠各种生理参数的药理作用。
该研究旨在量化不同提取方法中的黄酮类和酚类含量，重点关注乙醇提取物的卓越功效。
进行了[具体实验名称]测定以评估EEAT的抗氧化活性，揭示了剂量依赖性效应和显著的抑制百分比。
EEAT在扭体反应试验中表现出显著的镇痛作用，尤其是在200mg/kg时，表明其作为天然镇痛药的潜力。此外，在角叉菜胶诱导的爪肿胀模型中，其抗炎作用复杂且呈剂量依赖性。在啤酒酵母诱导发热后，该提取物在体温调节方面也表现出显著变化，呈现出先体温过低后逐渐回升的独特模式。此外，EEAT对胃肠蠕动具有调节作用，在炭末试验中，较高剂量可增强肠道转运。
本研究突出了EEAT作为抗氧化、镇痛、抗炎和胃肠调节天然治疗剂的药理潜力，值得进一步研究其作用机制和治疗应用。
