Boertz A K, Arnold D, Somogyi A
Z Ernahrungswiss. 1985 Jun;24(2):113-9. doi: 10.1007/BF02020458.
Residues of chloramphenicol (CAP) were examined in 24 pigs after intramuscular injection of 30 mg CAP/kg body weight. Two pigs were slaughtered after 3, 6, 12, 18, 24, 36 hours, 2, 3, 6, 10, 21 and 30 days, respectively. CAP-concentrations were determined in muscle, blood, urine, liver, kidney, bile, and fat. Methods used were gas-liquid chromatography and radioimmunoassay. Detection limits reached were 1-5 ppb. The concentration-time curves obtained reflected a long elimination phase and allowed only calculation of this half-life. Elimination half-life was estimated to be for muscle, blood and urine 160-170 hours, for kidney 310 and for bile 250 hours. Significant correlations were found to exist between CAP-concentrations in plasma and muscle. It appears that blood would be a good body fluid for monitoring CAP-residues in tissue.
对24头猪进行了研究，这些猪每千克体重肌肉注射30毫克氯霉素（CAP）。分别在注射后3、6、12、18、24、36小时以及2、3、6、10、21和30天宰杀2头猪。测定了肌肉、血液、尿液、肝脏、肾脏、胆汁和脂肪中的氯霉素浓度。所采用的方法是气液色谱法和放射免疫分析法。检测限达到1 - 5 ppb。所获得的浓度 - 时间曲线反映出一个较长的消除阶段，且仅能计算该半衰期。据估计，肌肉、血液和尿液的消除半衰期为160 - 170小时，肾脏为310小时，胆汁为250小时。发现血浆和肌肉中的氯霉素浓度之间存在显著相关性。看来血液将是监测组织中氯霉素残留的良好体液。
