Chelminiak-Dudkiewicz Dorota, Wujak Magdalena, Mlynarczyk Dariusz T, Dlugaszewska Jolanta, Mylkie Kinga, Smolarkiewicz-Wyczachowski Aleksander, Ziegler-Borowska Marta
Department of Biomedical Chemistry and Polymer Science, Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100, Torun, Poland.
Department of Medicinal Chemistry, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Jurasza 2, 85-089, Bydgoszcz, Poland.
Heliyon. 2024 Jul 31;10(15):e35389. doi: 10.1016/j.heliyon.2024.e35389. eCollection 2024 Aug 15.
Given the growing interest in non-toxic materials with good anti-inflammatory and antimicrobial mechanical properties, this work focuses on preparing chitosan sponges with violacein and cannabis oil crosslinked with dialdehyde chitosan. The sponge was tested for its physicochemical and biological properties, presenting a high swelling rate, good thermal stability, and satisfactory mechanical properties. The obtained sponge's water vapor transmission rate was 2101 g/m/day and is within the recommended values for ideal wound dressings. Notably, adding violacein favorably affected the material's porosity, which is essential for dressing materials. In addition, studies have shown that the designed material interacts with human serum albumin and exhibits good antioxidant and anti-inflammatory properties. The antibacterial properties of the prepared biomaterial were assessed using the Microtox test against (Gram-negative bacterium) and (Gram-positive bacterium). The investigated material provides potential therapeutic benefits due to the synergistic action of chitosan, violacein, and cannabis oil so that it could be used as a dressing material. The natural origin of the substances could provide an attractive and sustainable alternative to traditional commercially available dressings.
鉴于人们对具有良好抗炎、抗菌和机械性能的无毒材料的兴趣日益浓厚，本研究致力于制备用紫菌素和大麻油与二醛壳聚糖交联的壳聚糖海绵。对该海绵的物理化学和生物学性质进行了测试，结果表明其具有高膨胀率、良好的热稳定性和令人满意的机械性能。所制备海绵的水蒸气透过率为2101 g/m²/天，在理想伤口敷料的推荐值范围内。值得注意的是，添加紫菌素对材料的孔隙率有积极影响，这对敷料材料至关重要。此外，研究表明，所设计的材料与人血清白蛋白相互作用，并具有良好的抗氧化和抗炎性能。使用Microtox测试评估了所制备生物材料对（革兰氏阴性菌）和（革兰氏阳性菌）的抗菌性能。由于壳聚糖、紫菌素和大麻油的协同作用，所研究的材料具有潜在的治疗益处，因此可用作敷料材料。这些物质的天然来源可为传统市售敷料提供有吸引力的可持续替代品。
