Muthmainah Muthmainah, Wiyono Nanang, Syah Faris K, Purnianto Adityas, Yudhani Ratih D, Wasita Brian
Department of Anatomy, Faculty of Medicine, Universitas Sebelas Maret, Indonesia.
Doctoral Program in Medical Science, Faculty of Medicine, Universitas Sebelas Maret, Indonesia.
J Taibah Univ Med Sci. 2025 May 29;20(3):298-306. doi: 10.1016/j.jtumed.2025.05.004. eCollection 2025 Jun.
Parkinson's disease (PD) is a prevalent neurodegenerative disorder without a definitive cure. Oxidative stress is significantly implicated in its pathogenesis, prompting interest in N-acetylcysteine (NAC), a strong antioxidant and cysteine precursor, as a potential therapeutic agent. We conducted a bibliometric analysis of 421 Scopus articles to assess current trend and future potential of research on the use of NAC in Parkinson's disease. The number of publications related to this topic reached the peaked in 2010 and gradually decreased afterward. We identified 4 main clusters of research theme related to the potential mechanism of NAC effects on Parkinson's disease progression. These include research focusing on NAC effects on oxidative stress, dysfunction of the mitochondria, aberrant protein accumulation and clearance and inflammation. Investigating NAC effect for Parkinson's disease in human is a potential research area.
帕金森病（PD）是一种常见的神经退行性疾病，尚无确切的治愈方法。氧化应激在其发病机制中具有重要作用，这引发了人们对N-乙酰半胱氨酸（NAC）的兴趣，NAC是一种强大的抗氧化剂和半胱氨酸前体，有望成为一种潜在的治疗药物。我们对421篇Scopus文章进行了文献计量分析，以评估使用NAC治疗帕金森病的研究现状和未来潜力。与该主题相关的出版物数量在2010年达到峰值，之后逐渐减少。我们确定了与NAC对帕金森病进展影响的潜在机制相关的4个主要研究主题集群。这些包括聚焦于NAC对氧化应激、线粒体功能障碍、异常蛋白质积累和清除以及炎症影响的研究。研究NAC对人类帕金森病的影响是一个潜在的研究领域。
