Azizah Nur, Maesaroh Imas, Zahra Nabila Az, Alaydrus Syafika
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Health, and Science, Universitas Muhammadiyah Kuningan, Cigugur, West Java, Indonesia.
Department of Pharmaceutical Biology, Faculty of Pharmacy, Health, and Science, Universitas Muhammadiyah Kuningan, Cigugur, West Java, Indonesia.
J Adv Pharm Technol Res. 2025 Apr-Jun;16(2):106-110. doi: 10.4103/JAPTR.JAPTR_321_24. Epub 2025 May 19.
This study was conducted to evaluate the impact of a combination of fruit extract (MCFE) and leaf extract (ABLE) on hair growth in rabbits. The study included seven treatment groups: (1) control group (distilled water), (2) positive control (minoxidil 5%), (3) treatment 1 (MCFE 10%), (4) treatment 2 (ABLE 10%), (5) treatment 3 (MCFE 5% + ABLE 5%), (6) treatment 4 (MCFE 7.5% + ABLE 2.5%), and (7) treatment 5 (MCFE 2.5% + ABLE 7.5%). Hair length measurements were taken on days 7, 14, 21, and 28, and the average daily growth rate was calculated by dividing the change in hair length by the number of days. Hair weight was measured on day 28. Data analysis was conducted using both two-way and one-way ANOVA, and statistical significance was determined at < 0.05. The treatment group 4 (MCFE 7.5% + ABLE 2.5%) showed a significant difference in hair growth compared to the normal control, positive control, and other treatment groups ( < 0.05). The group exhibited a 19.69 ± 0.38 mm increase in hair length, with a daily growth rate of 0.88 mm/day, and an increase in hair weight of 0.33 ± 0.003 g. The combination of MCFE and ABLE demonstrated potential as an anti-hair loss agent, effectively enhancing both hair length and weight.
本研究旨在评估果实提取物(MCFE)和叶片提取物(ABLE)组合对家兔毛发生长的影响。该研究包括七个治疗组:(1)对照组(蒸馏水),(2)阳性对照(5%米诺地尔),(3)治疗组1(10% MCFE),(4)治疗组2(10% ABLE),(5)治疗组3(5% MCFE + 5% ABLE),(6)治疗组4(7.5% MCFE + 2.5% ABLE),以及(7)治疗组5(2.5% MCFE + 7.5% ABLE)。在第7、14、21和28天测量毛发长度,并通过将毛发长度变化除以天数来计算平均每日生长速率。在第28天测量毛发重量。使用双向和单向方差分析进行数据分析,统计学显著性设定为<0.05。与正常对照、阳性对照和其他治疗组相比,治疗组4(7.5% MCFE + 2.5% ABLE)在毛发生长方面显示出显著差异(<0.05)。该组毛发长度增加了19.69±0.38毫米,每日生长速率为0.88毫米/天,毛发重量增加了0.33±0.003克。MCFE和ABLE的组合显示出作为抗脱发剂的潜力,有效增加了毛发长度和重量。