Chaudhary Aru, More Akash, Choudhary Namrata, Barai Juhi, Wadhe Tejaswini
Department of Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India.
J Pharm Bioallied Sci. 2025 May;17(Suppl 1):S1015-S1018. doi: 10.4103/jpbs.jpbs_166_25. Epub 2025 Apr 17.
This case study represents a couple experiencing primary infertility for 4 years, with the male suffering from hypertension and normozoospermic condition, whereas the female suffers from Polycystic Ovary Syndrome (PCOS), which results in low ovarian reserve. The couple underwent the two failed IUI (Intrauterine Insemination) procedures and then was advised to go for Intra-cytoplasmic sperm injection (ICSI). After the first unsuccessful cycle of ICSI, the female patient underwent intraovarian platelet-rich plasma (PRP) therapy to improve the ovarian reserve and enhance egg quality. The second cycle of ICSI following the PRP treatment helped to improve ovarian response with more mature oocytes retrieved. After another ovum pick-up was conducted in which more mature oocytes were retrieved and after multiple embryo transfer (ET) cycles, a positive pregnancy was achieved. The patient was asked to have regular checkups during pregnancy. This study results in the potential benefit of intraovarian PRP therapy in enhancing ovarian function and reserve.
本案例研究呈现了一对经历了4年原发性不孕的夫妇，男方患有高血压且精子正常，而女方患有多囊卵巢综合征（PCOS），导致卵巢储备功能低下。这对夫妇接受了两次宫腔内人工授精（IUI）手术均失败，随后被建议进行卵胞浆内单精子注射（ICSI）。在第一个ICSI周期未成功后，女性患者接受了卵巢内富血小板血浆（PRP）治疗，以改善卵巢储备并提高卵子质量。PRP治疗后的第二个ICSI周期有助于改善卵巢反应，获取到更多成熟卵子。在又一次取卵并获取到更多成熟卵子后，经过多次胚胎移植（ET）周期，成功实现了妊娠。患者在孕期被要求定期进行检查。本研究表明卵巢内PRP治疗在增强卵巢功能和储备方面具有潜在益处。
