Pavlovic Voja, Ciric Milan, Jovanovic Vladimir, Stojanovic Predrag
Institute of Physiology, Medical Faculty University of Nis, Bulevar Dr. Zorana Djindjica 81, Nis, Serbia.
Institute of Physiology, Medical Faculty University of Nis, Nis, Serbia.
Open Med (Wars). 2016 Aug 12;11(1):242-247. doi: 10.1515/med-2016-0048. eCollection 2016.
Platelet rich plasma (PRP) represents a relatively new approach in regenerative medicine. It is obtained from patient's own blood and contains different growth factors and other biomolecules necessary for wound healing. Since there are various protocols for PRP preparing, it usually results with PRP generation with different amounts of bioactive substances, which finally may modulate the intensity of wound healing. The reference data about potential effect of some PRP compounds on wound healing, in different tissues, are still controversial. This review summarizes recently known facts about physiological role of certain PRP components and guidance for further research. Also, this review discusses different procedure for PRP generation and potential effect of leukocytes on wound healing.
富血小板血浆（PRP）是再生医学中一种相对较新的方法。它取自患者自身血液，含有伤口愈合所需的不同生长因子和其他生物分子。由于PRP制备有多种方案，通常会产生含有不同量生物活性物质的PRP，这最终可能会调节伤口愈合的强度。关于某些PRP化合物在不同组织中对伤口愈合的潜在作用的参考数据仍存在争议。本综述总结了关于某些PRP成分生理作用的最新已知事实以及进一步研究的指导。此外，本综述还讨论了PRP生成的不同程序以及白细胞对伤口愈合的潜在作用。
