Mujahed Shrouq, Janabel Jaysan, Shaw Kundan, Cagliani Roberta, Amatov Tynchtyk
The Division of Science, Chemistry Program, New York University Abu Dhabi, PO Box 129188, Abu Dhabi, UAE.
Angew Chem Int Ed Engl. 2025 Aug 11;64(33):e202511233. doi: 10.1002/anie.202511233. Epub 2025 Jun 24.
We report that nitrogen-centered persistent radicals, Kuhn verdazyls, are effective, tunable ground-state redox organocatalysts for single electron transfer (SET)-initiated radical transformations. Verdazyls uniquely emulate catalytic single-electron shuttling, a hallmark of redox catalysis, without light or external stimuli. They enable redox-neutral C─C bond-forming reactions, such as C─H arylation and C─H trifluoromethylation, typically driven by transition metals, photoredox catalysts, or mechanoredox mediators, while avoiding the self-inhibition that limits organic super electron donors and nitroxides in such applications.
我们报道，以氮为中心的持久性自由基，即库恩连氮自由基，是用于单电子转移（SET）引发的自由基转化的有效、可调节的基态氧化还原有机催化剂。连氮自由基独特地模拟了催化单电子穿梭，这是氧化还原催化的一个标志，无需光或外部刺激。它们能够实现氧化还原中性的C─C键形成反应，如C─H芳基化和C─H三氟甲基化，这些反应通常由过渡金属、光氧化还原催化剂或机械氧化还原介质驱动，同时避免了在这类应用中限制有机超电子供体和氮氧化物的自抑制作用。
