从调控到功能：特殊代谢的计算方法
Regulation to function: A computational approach to specialized metabolism.
作者信息
Nodwell Justin R
机构信息
Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
出版信息
PLoS Biol. 2025 Jun 13;23(6):e3003205. doi: 10.1371/journal.pbio.3003205. eCollection 2025 Jun.
Abstract
Despite a century of use in drug discovery, specialized metabolism continues to churn out astonishing discoveries. A new study in PLOS Biology uses a novel computational approach to uncover previously unknown functions of a compound produced by Streptomyces coelicolor.
摘要
尽管在药物研发中已应用了一个世纪，但特殊代谢仍不断带来惊人发现。发表于《公共科学图书馆·生物学》的一项新研究采用了一种新颖的计算方法，以揭示天蓝色链霉菌产生的一种化合物此前未知的功能。
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本文引用的文献
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Genome mining based on transcriptional regulatory networks uncovers a novel locus involved in desferrioxamine biosynthesis.基于转录调控网络的基因组挖掘揭示了一个参与去铁胺生物合成的新位点。
PLoS Biol. 2025 Jun 12;23(6):e3003183. doi: 10.1371/journal.pbio.3003183. eCollection 2025 Jun.
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Streptomyces umbrella toxin particles block hyphal growth of competing species.链霉菌伞状毒素颗粒可阻止竞争物种的菌丝生长。
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antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences.antiSMASH：快速识别、注释和分析细菌和真菌基因组序列中次生代谢产物生物合成基因簇。
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Phosphorylated AbsA2 negatively regulates antibiotic production in Streptomyces coelicolor through interactions with pathway-specific regulatory gene promoters.磷酸化的AbsA2通过与途径特异性调控基因启动子相互作用，对天蓝色链霉菌中的抗生素产生负调控作用。
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The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus : identification of a target gene of the A-factor receptor.导致灰色链霉菌中链霉素生物合成的A因子调控级联反应：A因子受体的一个靶基因的鉴定
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