Blecha F, Pollmann D S, Nichols D A
Am J Vet Res. 1985 Sep;46(9):1934-7.
Using 64 pigs, 2 experiments (32 pigs each) were conducted to evaluate the effects of regrouping nonlittermate pigs at weaning or 2 weeks after weaning on mitogen-induced lymphocyte blastogenesis, intradermal reactions to phytohemagglutinin, and primary antibody responses to sheep erythrocytes. Plasma cortisol concentrations were determined in all pigs and behavior of regrouped pigs was monitored. Compared with control values, plasma cortisol concentrations were higher in nonlittermate pigs regrouped at weaning (P less than 0.001) or 2 weeks after weaning (P less than 0.01). However, regrouping pigs at weaning or 2 weeks after weaning did not influence lymphocyte blastogenesis, phytohemagglutinin skin-test responses, or antibody titers to sheep erythrocytes. Plasma cortisol concentrations were not related to agonistic behavior in regrouped pigs or to lymphocyte blastogenic or phytohemagglutinin skin-test responses; however, higher plasma cortisol concentrations were related (P less than 0.05) to lower sheep erythrocyte antibody titers. These data indicate that regrouping nonlittermate pigs at weaning or 2 weeks after weaning is an acute stressor that does not detrimentally affect mitogen-induced lymphocyte blastogenesis, intradermal reactions to phytohemagglutinin, or primary antibody responses to sheep erythrocytes.
利用64头猪进行了2项试验（每项试验32头猪），以评估断奶时或断奶后2周对非同窝仔猪进行重新组群对丝裂原诱导的淋巴细胞增殖、对植物血凝素的皮内反应以及对绵羊红细胞的初次抗体反应的影响。测定了所有猪的血浆皮质醇浓度，并监测了重新组群猪的行为。与对照值相比，断奶时（P<0.001）或断奶后2周（P<0.01）重新组群的非同窝仔猪血浆皮质醇浓度更高。然而，在断奶时或断奶后2周对猪进行重新组群并不影响淋巴细胞增殖、植物血凝素皮肤试验反应或对绵羊红细胞的抗体滴度。血浆皮质醇浓度与重新组群猪的攻击行为或淋巴细胞增殖或植物血凝素皮肤试验反应无关；然而，较高的血浆皮质醇浓度与较低的绵羊红细胞抗体滴度相关（P<0.05）。这些数据表明，在断奶时或断奶后2周对非同窝仔猪进行重新组群是一种急性应激源，不会对丝裂原诱导的淋巴细胞增殖、对植物血凝素的皮内反应或对绵羊红细胞的初次抗体反应产生不利影响。
