Enarson D A, Vedal S, Chan-Yeung M
Am Rev Respir Dis. 1985 Oct;132(4):814-7. doi: 10.1164/arrd.1985.132.4.814.
We have prospectively studied the respiratory health of a cohort of grain elevator workers in the Canadian west coast terminal elevators, beginning in 1975 and following them for 6 yr. We have used a "nested" case-control model to identify determinants of the worst trend in FEV1 over this period. The 10% of participants in this category had a mean decline of greater than 100 ml/yr. They were significantly more likely to have had a decline in FEV1 over a work week and to have nonspecific bronchial hyperreactivity. There was a significant relationship between the odds ratio of being a case and the mean level of dust exposure associated with the job and location at the work site; cases were associated with mean total dust levels greater than 5 mg/m3. We found no relationship between the odds ratio of being a case and a number of host factors, such as immediate skin reactivity to common allergens, history of asthma, bronchitis, or hay fever, or presence of respiratory symptoms. We conclude that exposure to grain dust at levels greater than 5 mg/m3 is associated with a serious adverse trend in FEV1.
自1975年起，我们对加拿大西海岸码头升降机的一组谷物升降机工人的呼吸健康状况进行了前瞻性研究，并对他们进行了6年的跟踪调查。我们采用了“嵌套”病例对照模型来确定这一时期第一秒用力呼气容积（FEV1）最严重下降趋势的决定因素。这一类别的10%参与者平均每年下降超过100毫升。他们在一个工作周内FEV1下降以及出现非特异性支气管高反应性的可能性显著更高。成为病例的比值比与工作和工作场所位置相关的平均粉尘暴露水平之间存在显著关系；病例与平均总粉尘水平大于5毫克/立方米相关。我们发现成为病例的比值比与一些宿主因素之间没有关系，如对常见过敏原的即时皮肤反应性、哮喘、支气管炎或花粉热病史，或呼吸道症状的存在。我们得出结论，暴露于大于5毫克/立方米的谷物粉尘与FEV1的严重不良趋势相关。
