Deng Min, Yuan Xihua, Zhu Xiaoying, Wei Jiaqiang, Li Minsi, Yang Ziyi, Yu Na, Qin Xiaofeng
Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China; Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Baise, China.
Department of Dermatology and Venerology, The Second Affiliated Hospital, Guangxi Medical University, Nanning, China.
Int Dent J. 2025 Jun 12;75(4):100841. doi: 10.1016/j.identj.2025.100841.
Untreated dental caries in permanent teeth is a significant public health problem, particularly in Asia. This study compared the long-term trends in the incidence, prevalence, and disability-adjusted life year (DALY) rates of untreated dental caries in permanent teeth between China, India, Japan, South Korea, Thailand, and Singapore from 1990 to 2021. This selection provides a comprehensive representation of economic, healthcare, and demographic diversity in Asia, making our findings widely applicable.
Data were obtained from the Global Burden of Disease Study 2021. Changes in both the annual percentage and average annual percentage were calculated using joinpoint regression analysis. Independent age, period, and cohort effects were estimated by age-period-cohort analysis.
From 1990 to 2021, the overall age-standardized incidence rate showed an increasing trend in China, India, and Thailand and a decreasing trend in Japan, Korea, and Singapore. The standardized prevalence and DALY rates decreased among countries, with Korea having the highest prevalence rate and India and Thailand having the highest prevalence and DALY rates. On age-period-cohort analysis, (1) the 20 to 24-year age group carried the highest caries risk, which declined with increasing age (age effect); (2) an overall decreasing or flat trend was observed (period effect); and (3) Japan, Singapore, and South Korea showed increasing incidence, prevalence, and DALY rates, whereas China, India, and Thailand exhibited decreasing prevalence and DALY rates (cohort effect).
This study revealed notable regional variations in the burden of untreated dental caries in permanent teeth across Asia from 1990 to 2021. These findings provide valuable insights for policymakers and healthcare professionals to develop targeted and evidence-based oral health strategies in the region.
These findings underscore the need to develop targeted oral health solutions in Asia.
恒牙未治疗龋齿是一个重大的公共卫生问题，在亚洲尤为突出。本研究比较了1990年至2021年期间中国、印度、日本、韩国、泰国和新加坡恒牙未治疗龋齿的发病率、患病率和伤残调整生命年（DALY）率的长期趋势。这一选择全面呈现了亚洲的经济、医疗保健和人口多样性，使我们的研究结果具有广泛适用性。
数据来自《2021年全球疾病负担研究》。使用Joinpoint回归分析计算年度百分比变化和平均年度百分比变化。通过年龄-时期-队列分析估计独立的年龄、时期和队列效应。
1990年至2021年期间，中国、印度和泰国的总体年龄标准化发病率呈上升趋势，而日本、韩国和新加坡呈下降趋势。各国的标准化患病率和DALY率均有所下降，韩国的患病率最高，印度和泰国的患病率和DALY率最高。在年龄-时期-队列分析中，（1）20至24岁年龄组的龋齿风险最高，且随年龄增长而下降（年龄效应）；（2）观察到总体呈下降或平稳趋势（时期效应）；（3）日本、新加坡和韩国的发病率、患病率和DALY率呈上升趋势，而中国、印度和泰国的患病率和DALY率呈下降趋势（队列效应）。
本研究揭示了1990年至2021年期间亚洲恒牙未治疗龋齿负担存在显著的区域差异。这些发现为政策制定者和医疗保健专业人员制定该地区有针对性的、基于证据的口腔健康策略提供了有价值的见解。
这些发现强调了在亚洲制定有针对性的口腔健康解决方案的必要性。
