Liu A J, Richardson M A
Ann Otol Rhinol Laryngol. 1985 Sep-Oct;94(5 Pt 1):477-82. doi: 10.1177/000348948509400513.
The effects of N-acetylcysteine (NAC) in the treatment of caustic alkaline injury to the esophagus is examined. Caustic esophageal burns were produced in rats by irrigation with NaOH. Stricture formation was less frequent in animals concurrently treated with either steroids (48%) or NAC (48%) than in control animals that received only the alkaline injury (74%). In addition, the severity of stenosis was less in drug-treated rats. Thirty percent of strictures in control animals were severe (3 +) compared to 6% in the NAC group and 7% in the steroid group. Both NAC and steroids would seem to ameliorate the tissue reaction to chemical injury as well as temper the degree of stenosis formation. Possibility of synergistic effects warrants future investigation.
研究了N-乙酰半胱氨酸（NAC）治疗食管碱性腐蚀伤的效果。通过用氢氧化钠冲洗在大鼠中造成腐蚀性食管烧伤。与仅接受碱性损伤的对照动物（74%）相比，同时接受类固醇（48%）或NAC（48%）治疗的动物中狭窄形成的频率较低。此外，药物治疗的大鼠中狭窄的严重程度较低。对照动物中30%的狭窄为重度（3+），而NAC组为6%，类固醇组为7%。NAC和类固醇似乎都能改善组织对化学损伤的反应，并减轻狭窄形成的程度。协同效应的可能性值得未来研究。
