Umoh I B, Ogunkoya F O, Maduagwu E N, Oke O L
Ann Nutr Metab. 1985;29(5):319-24. doi: 10.1159/000176987.
The effect of graded levels of thiamin on the metabolism of linamarin was investigated in rats. It was observed that on a diet deficient in thiamin, a large amount of linamarin was recovered unchanged in the urine, together with significantly more thiocyanate (SCN-) relative to the control. The least amount of thiocyanate (p less than 0.05 relative to control) was found in animals receiving the highest amount (twice daily requirement) of thiamin in the diet; but the amount of unmetabolized linamarin was similar to the control. It is suggested that thiamin deficiency may be implicated in the aetiology of tropical ataxic neuropathy (TAN) through the thiocyanate overload in people eating large amounts of cassava and cassava derivatives which contain linamarin.
研究了不同剂量硫胺素对大鼠中亚麻苦苷代谢的影响。观察到，在缺乏硫胺素的饮食条件下，大量亚麻苦苷原样从尿液中回收，同时相对于对照组，硫氰酸盐（SCN-）的含量显著增加。在饮食中摄入最高剂量（每日需求量的两倍）硫胺素的动物中，硫氰酸盐的含量最少（相对于对照组，p<0.05）；但未代谢的亚麻苦苷含量与对照组相似。有人提出，食用大量含有亚麻苦苷的木薯和木薯衍生物的人群，由于硫氰酸盐过载，硫胺素缺乏可能与热带共济失调性神经病（TAN）的病因有关。
