大鼠口服亚麻苦苷的代谢情况。
Fate of orally dosed linamarin in the rat.
作者信息
Barrett M D, Hill D C, Alexander J C, Zitnak A
出版信息
Can J Physiol Pharmacol. 1977 Feb;55(1):134-6. doi: 10.1139/y77-021.
DOI:10.1139/y77-021
PMID:843989
Abstract
Wistar rats, about 100 g in weight, were dosed by stomach tube with 30 mg of pure linamarin. No intact linamarin was identified in the feces or blood but 5.65 mg was excreted in the urine along with 0.823 mg of thiocyanate ion. A 50-mg dose of linamarin was lethal to 7 of 10 rats receiving this dose.
摘要
体重约100克的Wistar大鼠通过胃管给予30毫克纯亚麻苦苷。在粪便或血液中未检测到完整的亚麻苦苷，但尿液中排出了5.65毫克，同时还有0.823毫克硫氰酸根离子。50毫克剂量的亚麻苦苷对接受该剂量的10只大鼠中的7只具有致死性。
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