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碱基编辑技术在研究病毒-宿主相互作用及抗病毒治疗策略中的应用

The Application of Base-Editing Technology to Investigate Virus-Host Interactions and Antiviral Therapeutic Strategies.

作者信息

Zhou Quan, Wu Tong, Zheng Chunfu, Zou Xiaodong

机构信息

Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong, China.

Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada.

出版信息

Methods Mol Biol. 2025;2940:251-260. doi: 10.1007/978-1-0716-4615-1_22.

Abstract

Understanding viral pathogenesis and developing effective countermeasures hinge on deciphering the complex relationships between viruses and their hosts. While conventional approaches have shown limitations in unraveling these intricate interactions, researchers are now turning to cutting-edge genetic tools, particularly base-editing technology. This section explores how base editing can be innovatively applied to investigate virus-host dynamics and to create novel antiviral therapeutic approaches.

摘要

了解病毒发病机制并制定有效的应对措施取决于破解病毒与其宿主之间的复杂关系。虽然传统方法在揭示这些复杂的相互作用方面存在局限性,但研究人员现在正转向前沿的基因工具,特别是碱基编辑技术。本节探讨碱基编辑如何能够创新性地应用于研究病毒-宿主动态关系,并创造新的抗病毒治疗方法。

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