类风湿性关节炎患者的白细胞功能：体内白细胞定量动员及血液和渗出液白细胞的体外功能
Leucocyte function in patients with rheumatoid arthritis: quantitative in-vivo leucocyte mobilisation and in-vitro functions of blood and exudate leucocytes.
作者信息
Wandall J H
出版信息
Ann Rheum Dis. 1985 Oct;44(10):694-700. doi: 10.1136/ard.44.10.694.
Abstract
Quantitative leucocyte mobilisation in vivo and the in-vitro random migration, chemotaxis, phagocytosis, and oxidative metabolic activity were studied in 15 patients with rheumatoid arthritis (RA). Patients mobilised leucocytes to chambers covering skin windows to the same degree as control subjects, and the mobilisation correlated with the blood leucocyte numbers and serum concentration of alpha-l-antitrypsin. Peripheral blood leucocytes showed slightly reduced migration in Boyden chambers but increased phagocytosis and increased unstimulated reduction of nitroblue tetrazolium. Exudate leucocytes from patients with RA showed migratory and phagocytic activity which did not differ from that of control subjects, but unstimulated exudate leucocytes reduced nitroblue tetrazolium more actively than leucocytes from control subjects. The observations indicate that leucocyte accumulation at an experimental inflammatory lesion and the function of these exudate leucocytes are not impaired in patients with rheumatoid arthritis.
摘要
对15例类风湿性关节炎（RA）患者进行了体内白细胞定量动员以及体外随机迁移、趋化性、吞噬作用和氧化代谢活性的研究。患者将白细胞动员到覆盖皮肤窗口的小室中的程度与对照组受试者相同，且这种动员与血液白细胞数量和α1抗胰蛋白酶血清浓度相关。外周血白细胞在博伊登小室中的迁移略有减少，但吞噬作用增强，未刺激时对硝基蓝四氮唑的还原增加。类风湿性关节炎患者的渗出液白细胞显示出与对照组受试者无异的迁移和吞噬活性，但未刺激的渗出液白细胞比对照组受试者的白细胞更活跃地还原硝基蓝四氮唑。这些观察结果表明，类风湿性关节炎患者在实验性炎症病变处的白细胞积聚以及这些渗出液白细胞的功能并未受损。
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